Donidalorsen

Donidalorsen (API)

Gusaba Ubushakashatsi:
Donidalorsen API ni antisense oligonucleotide (ASO) iri gukorwaho iperereza kugirango ivure umurage wa angioedema (HAE) hamwe nindwara ziterwa na inflammatory. Yizwe murwego rwa RNA igamije kuvura, igamije kugabanya imvugo yaplasma prekallikrein(KLKB1 mRNA). Abashakashatsi bifashisha Donidalorsen kugira ngo basuzume uburyo bwo gucecekesha gene, imiti iterwa na farumasi, no kugenzura igihe kirekire kurwanya indwara ya bradykinin.

Imikorere:
Imikorere ya Donidalorsen muguhitamo guhuzaKLKB1mRNA, kugabanya umusaruro wa plasma prekallikrein - enzyme yingenzi muri sisitemu ya kallikrein-kinin ishinzwe gukurura kubyimba no gutwika muri HAE. Mugabanye urugero rwa kallikrein, Donidalorsen ifasha gukumira ibitero bya HAE no kugabanya umutwaro windwara. Nka API, ikora nkibikoresho byingenzi byo kuvura mugutezimbere igihe kirekire, gikoreshwa muburyo butemewe bwo kuvura HAE.