Etelcalcetide Hydrochloride
Etelcalcetide Hydrochloride API
Etelcalcetide Hydrochloride nigitabo gishya cyitwa peptide calcide yimiti yakozwe mugukiza hyperparathiyideyumu ya kabiri (SHPT) kubarwayi barwaye impyiko zidakira (CKD) batewe na hemodialyse. SHPT ni ingorane zisanzwe kandi zikomeye ku barwayi ba CKD, zirangwa no kuzamura imisemburo ya parathiyide (PTH), guhagarika calcium-fosifate metabolism, no kongera ibyago byo kurwara amagufwa n'umutima.
Etelcalcetide igereranya igisekuru cya kabiri calcimimetike, itangwa mu mitsi, kandi itanga ibyiza kuruta kuvura umunwa mbere nka cinacalcet mugutezimbere kubahiriza no kugabanya ingaruka mbi zo munda.
Uburyo bwibikorwa
Etelcalcetide ikora muguhuza no gukora calcium-sensing reseptor (CaSR) iherereye muri selile ya parathiyide. Ibi bigana ingaruka za physiologique ya calcium idasanzwe, biganisha kuri:
Kurwanya gusohora kwa PTH
Kugabanuka kwa calcium ya calcium na fosifeti
Kunoza imyunyu ngugu no guhinduranya amagufwa
Nka peptide ishingiye kuri allosteric activateur ya CaSR, Etelcalcetide yerekana umwihariko hamwe nibikorwa bihoraho nyuma yubuyobozi bwimitsi nyuma ya dialyse.
Ubushakashatsi bwa Clinical n'ingaruka zo kuvura
Etelcalcetide yasuzumwe cyane mugice cya 3 cyamavuriro, harimo na EVOLVE, AMPLIFY, na EQUIP. Ibisubizo by'ingenzi birimo:
Kugabanuka gukomeye kandi kurambye kurwego rwa PTH kubarwayi ba CKD kuri hemodialyse
Kugenzura neza calcium ya calcium na fosifore, bigira uruhare mugutezimbere amagufa-minerval homeostasis
Kwihanganirana neza ugereranije na calcimimetics yo mu kanwa (isesemi nke no kuruka)
Kunoza kubahiriza abarwayi kubera gatatu-buri cyumweru ubuyobozi bwa IV mugihe cya dialyse
Izi nyungu zituma Etelcalcetide ihitamo uburyo bukomeye bwo kuvura ababana na neprologue bayobora SHPT mubantu ba dialyse.
Ubwiza no Gukora
Etelcalcetide Hydrochloride API:
Ihinduranya binyuze muri synthesis ya peptide ikomeye (SPPS) hamwe nubuziranenge bwinshi
Ihuza ibya farumasi-urwego rwihariye, ibereye gutera inshinge
Erekana urwego rwo hasi rwumuti usigaye, umwanda, na endotoxine
Nibipimwa kuri GMP-yubahiriza umusaruro-mwinshi
