Fitusiran

Fitusiran (API)

Gusaba Ubushakashatsi:
Fitusiran API ni sintetike ntoya yivanga RNA (siRNA) yakozweho iperereza cyane cyane mubijyanye na hemofilia n'indwara ya coagulation. Ireba iantithrombine (AT cyangwa SERPINC1)gene mu mwijima kugirango igabanye umusaruro wa antithrombine. Abashakashatsi bifashisha Fitusiran kugira ngo basuzume uburyo RNA yivanga (RNAi), gucecekesha gene yihariye y’umwijima, hamwe n’ingamba zo kuvura udushya zo kongera guhuza imitsi mu barwayi ba hémofilia A na B, hamwe na inhibitor.

Imikorere:
Fitusiran ikora mugucecekesha imvugo ya antithrombine, anticagulant naturel, bityo bikongera ibisekuruza bya trombine no guteza imbere imiterere. Ubu buryo butanga uburyo bwo kuvura indwara zo kugabanya amaraso mu barwayi ba hemofilia. Nka API, Fitusiran ikora nkibintu byingenzi mubuvuzi bumara igihe kirekire buvura bugamije kuzamura imibereho no kugabanya umutwaro wo kuvura indwara ziterwa no kuva amaraso.