GnRH Antagonist Yifashishijwe kuri Peptide Synthesis
Ibicuruzwa birambuye
| NO | Ibicuruzwa | URUBANZA No. | Gusaba | Ibipimo ngenderwaho byingenzi | ||||
| Isuku | Isomer | Umwanda wihariye | * Max1 | Ubushuhe | ||||
| 1 | Fmoc-3- (2-naphthyl) -D-Ala-OH | 138774-94-4 | Ibicuruzwa byinshi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 2 | Ac-3- (2-naphthyl) -D-Ala-OH | 37440-01-0 | Ibicuruzwa byinshi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 3 | Fmoc-3- (3-pyridinyl) -D-Ala-OH | 142994-45-4 | Ibicuruzwa byinshi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 4 | Fmoc-4-chloro-D-Phe-OH | 142994-19-2 | Ibicuruzwa byinshi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 5 | Fmoc-D-Cit-OH | 200344-33-8 | Cetrorelix | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤1.0% |
| 6 | Fmoc-D-Ala-OH.H2O | 79990-15-1 | Ibicuruzwa byinshi | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | .5 6.5% |
| 7 | Fmoc-D-Aph (tBuCbm) -OH | 1433975-21-3 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 8 | Fmoc-D-Aph (Cbm) -OH | 324017-22-3 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 9 | Fmoc-L-Aph (L-Hor) -OH | 1253282-31-3 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 10 | Fmoc-L-Lys (iPr, Boc) -OH | 201003-48-7 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 11 | Fmoc-N-Me-Tyr (tBu) -OH | 133373-24-7 | Abarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 12 | Fmoc-D-Asn (Trt) -OH | 180570-71-2 | Abarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 13 | Fmoc-HomoArg (Et) 2-OH.HCl | 1864003-26-8 | Ganirelix | ≥95.0% | ≤0.5% | ≤1.0% | ≤2.0% | ≤2.0% |
| 14 | Fmoc-D-HomoArg (Et) 2-OH.HCl | 2098497-24-4 | Ganirelix | ≥95.0% | ≤0.5% | ≤1.0% | ≤2.0% | ≤2.0% |
| 15 | Fmoc-Lys (nicotinoyl) -OH | 252049-11-9 | Kurwanya | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
| 16 | Fmoc-D-Lys (nicotinoyl) -OH | 252049-12-0 | Kurwanya | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
* Max1 = Umwanda utazwi
Ibindi bipimo:
- Acide Acike: ≤0.02% (Ibicuruzwa byose)
- Ethyl Acetate: ≤0.5% (Ibicuruzwa byose)
- Inzoga: ≤0.5% (Ibicuruzwa byose)
TOC hamwe nuyobora
TOC hamwe nuburyo bwiza bwo gutanga no kugaruka bikurikiranwa buri gihe. TOC ikurikiranwa na QC buri cyumweru. Imikorere ikurikiranwa kumurongo kandi ikandikwa nuwashinzwe amazi meza asukuye rimwe mumasaha ane. Imikorere ikurikiranwa kuri RO ibanza, RO yisumbuye, EDI hamwe nibisubizo byose byo kugabura sisitemu. Ibisobanuro by'amazi meza birahari kandi bihuye nibisobanuro byateganijwe mbere bitarenze 1.3 µs / cm kuri 25 ° C (USP). Kubintu nyamukuru byo gutanga no kugaruka, ikizamini cyuzuye. ikorwa buri cyumweru, kubindi ukoresheje ingingo mukuzenguruka, ikizamini cyuzuye gikorwa rimwe mukwezi. Ikizamini cyuzuye kirimo inyuguti, pH, nitrate, nitrite, ammonia, imiyoboro, TOC, ibintu bidahindagurika, ibyuma biremereye, imipaka ya mikorobe na endotoxine ya bagiteri.
