Inclisiran sodium

Inclisiran Sodium (API)

Gusaba Ubushakashatsi:
Inclisiran sodium API (Active Pharmaceutical Ingredient) yizwe cyane cyane mubijyanye no kwivanga kwa RNA (RNAi) hamwe nubuvuzi bwumutima. Nka siRNA ikubye kabiri yibasira gene PCSK9, ikoreshwa mubushakashatsi bwibanze nubuvuzi kugirango isuzume ingamba zimaze igihe zicecekesha gene yo kugabanya LDL-C (cholesterol ya lipoprotein nkeya). Ikora kandi nk'icyitegererezo cyo gukora iperereza kuri sisitemu yo gutanga siRNA, ituze, hamwe na RNA ivura umwijima.

Imikorere:
Inclisiran sodium API ikora mugucecekesha gene PCSK9 muri hepatocytes, bigatuma umusaruro wa proteine ​​PCSK9 ugabanuka. Ibi bivamo kongera uburyo bwo kongera gukoresha reseptor ya LDL no gukuraho cholesterol ya LDL mu maraso. Imikorere yacyo nka cholesterol igabanya igihe kirekire igabanya imikoreshereze yayo mukuvura hypercholesterolemia no kugabanya ibyago byindwara zifata umutima. Nka API, igizwe nibintu byingenzi bigize ibiyobyabwenge bya Inclisiran.