Acadia Trofinetide Icyiciro cya III IILI CLINICAL THE-LINK Ibisubizo byiza

Ku ya 2021-12-06, Amerika, Acadia Farumasicts (NASDAQ: ACAD) yatangaje ibyavuye kumurongo mwiza wa III ya III ya III ya III ya III, Trofinetde. Ikigeragezo cya III cya III, cyitwa Lavender, gikoreshwa cyane mu gusuzuma umutekano n'imikorere ya Trofinetde mu kuvura syndrome ya rett (amafaranga). Amasomo yose 189 yiyandikishije, abagore bose bafite imyaka 5-20 ifite amafaranga

Lavender yari impumyi ebyiri, idateganijwe, igenzurwa-igenzurwa ryibyumweru 12 hamwe nimpeshyi yibanze ya rsviointle ikibazo cyamafaranga (CGI-I), nkuko bisuzumwa nabakozi bonsa nabaganga; Urufunguzo Impera za kabiri ni Itumanaho ryiterambere nicyiciro cyikigereranyo ku mpinja n'abana bato (CSBS-DP-IT-IBIKORWA BIKORESHEJWE MU GIKORWA CY'IMBERE KANDI BIKORESHEJWE N'AMAHANGA Y'ITERAMBANYI.

Ibisubizo byerekanaga ko Trofinetde yari ifitanye isano cyane haba kumpera yibanze ugereranije na papa. Impinduka ziva muri Baseline muri RSBQ kubanyamaguru na TrofineTetide mucyumweru cya 12 byari -1.7 vs -5.1 (p = 0.0175); CGI-I amanota yari 3.8 vs 3.5 (P = 0.0030). Hagati aho, impinduka ziva mu bikorwa muri CSBS-DP-mibereho-mibereho yari -1.1 na -0.1 kubibanza no gutwika trofinet.

Ibitekerezo byibanze nibyiciro byibanze bya Lavender byerekanaga ubushobozi bwa Trofinetde yo kuvura amafaranga ariko, hakwiye kuvugwa ko igipimo cyo kuvura indwara ya trofinetide (icyayi) cyari kinini, bombi na 17.2%. Muri bo, ibintu bimeze nabi byari:

Learrhea - Trofinetde yari 80.6% (97.3% muri byo byari byoroheje kugeza biringaniye) na Placebo yari 19.1%;

Kuruka - Trofinetde yari 26.9% (96% byacyo byari byoroheje kugeza buringaniye) na placebo byari 4,6%;

Ibintu bikomeye bibi byabaye muri 3,2% byamasomo mumatsinda yombi.

Ingingo ziri mu rubanza rwa Lavender zizakomeza kwakira Trofinetde nyuma yo kurangiza urubanza cyangwa muri Lilac-lalac-2 Inyigisho zo Kwagura ULLAC