GH / IGF-1 igabanya physiologique uko imyaka igenda ishira, kandi izi mpinduka ziherekejwe numunaniro, atrophy yimitsi, kwiyongera kwa adipose, hamwe no kwangirika kwubwenge mubasaza…
Mu 1990, Rudman yasohoye urupapuro mu kinyamakuru cyitwa New England Journal of Medicine cyatunguye abaganga - “Gukoresha imisemburo ikura ya muntu mu bantu barengeje imyaka 60”.Rudman yahisemo abagabo 12 bafite imyaka 61-81 kugirango bagerageze kwa muganga:
Nyuma y'amezi 6 yatewe inshinge za HGH, amasomo yiyongereyeho 8.8% mubwinshi bwimitsi, 14.4% mugutakaza amavuta, 7.11% mubyibushye byuruhu, 1,6% mubucucike bwamagufwa, 19% mumwijima na 17% mumyanya ugereranije no kugenzura itsinda ryabandi basaza banganya imyaka.%, hanzuwe ko impinduka zamateka mumasomo yose yari muto kumyaka 10 kugeza kuri 20.
Uyu mwanzuro watumye abantu benshi bakwirakwiza imisemburo ikura ya recombinant (rhGH) nk'umuti urwanya gusaza, kandi ni nayo ntandaro y’uko abantu benshi bemeza ko gutera rhGH bishobora kurwanya gusaza.Kuva icyo gihe, abaganga benshi bakoresheje hGH nk'umuti urwanya gusaza, nubwo bitemewe na FDA.
Icyakora, uko ubushakashatsi bukomeje kwiyongera, abahanga mu bya siyansi basanze inyungu nto ku mubiri zo kongera ibikorwa bya axe ya GH / IGF-1 zitongera igihe cyo kubaho kwabasaza, ahubwo bitera ingaruka ku buzima:
Imbeba zirenze urugero GH ni nini, ariko zifite 30% -40% igihe gito cyo kubaho kurenza imbeba zo mu gasozi [2], kandi impinduka za histopathologique (glomerulosclerose na hepatocyte ikwirakwizwa) zibaho mu mbeba zifite urugero rwa GH rwinshi.binini) hamwe no kurwanya insuline.
Urwego rwo hejuru rwa GH rutera imikurire yimitsi, amagufwa, ningingo zimbere, biganisha kuri gigantism (mubana) na acromegaly (mubantu bakuru).Abakuze bafite GH irenze urugero usanga akenshi bifitanye isano na diyabete nibibazo byumutima, kimwe na kanseri nyinshi.
Igihe cyoherejwe: Nyakanga-22-2022