Icyiciro cya 2 Ikigeragezo cya Clinical ya Retatrutide, Triple Hormone-Receptor Agonist, yo kuvura umubyibuho ukabije

Amavu n'amavuko

Retatrutide (LY3437943) nigitabo gishya cya peptide ikorabitatu byakira icyarimwe: GIP, GLP-1, na glucagon. Kugirango hamenyekane akamaro kayo n’umutekano ku bantu bafite umubyibuho ukabije ariko nta diyabete, icyiciro cya 2, giteganijwe, impumyi ebyiri, igenzurwa na platbo (NCT04881760). Igiteranyo cyaAbitabiriye 338hamwe na BMI ≥30, cyangwa ≥27 byibuze byibuze kimwe kijyanye n'uburemere, bahisemo kwakira umwanya wa retbo cyangwa retatrutide (mg 1, mg 4 hamwe na gahunda ebyiri, titre 8 mg hamwe na titre ebyiri, cyangwa mg 12) byatanzwe rimwe mubyumweru no gutera inshinge mucyumweru 48. Uwitekaiherezo ryibanzeyari ihinduka ryijanisha ryibiro byumubiri mubyumweru 24, hamwe nibisobanuro bya kabiri harimo guhindura ibiro mubyumweru 48 hamwe no kugabanya ibiro (≥5%, ≥10%, ≥15%).

Ibisubizo by'ingenzi

• Ibyumweru 24: Byibuze-kare bisobanura ihinduka ryijana muburemere bwumubiri ugereranije na baseline yari

  • Ikibanza: −1,6%

  • 1 mg: −7.2%

  • 4 mg (hamwe): −12.9%

  • 8 mg (hamwe): −17.3%

  • 12 mg: −17.5%

• Ibyumweru 48: Guhindura ijanisha muburemere bwumubiri byari

  • Ikibanza: −2.1%

  • 1 mg: −8.7%

  • 4 mg (hamwe): −17.1%

  • 8 mg (hamwe): −22.8%

  • 12 mg: −24.2%

Mugihe cibyumweru 48, umubare wabitabiriye kugera kubipimo byo kugabanya ibiro bifite akamaro:

• ≥5% gutakaza ibiro: 27% hamwe na placebo na 92-100% mumatsinda akora

• ≥10%: 9% hamwe na placebo na 73-93% mumatsinda akora

• ≥15%: 2% hamwe na placebo na 55-83% mumatsinda akora

Mu itsinda rya mg 12, kugeza kuri26% by'abitabiriye amahugurwa batakaje ≥30% by'uburemere bwabo, ubunini bwo kugabanya ibiro ugereranije no kubaga ibibari.

Umutekano
Ibintu byakunze kugaragara nabi ni gastrointestinal (isesemi, kuruka, impiswi), mubisanzwe byoroheje bikabije kandi bikabije. Intangiriro yo gutangira (2 mg titre) yagabanije ibyabaye. Ubwiyongere bujyanye no kwiyongera k'umutima bwagaragaye, bugera ku cyumweru cya 24, hanyuma bugabanuka. Igipimo cyo guhagarika cyari hagati ya 6-16% mumatsinda akora, murwego rwo hejuru kurenza umwanya.

Umwanzuro
Ku bantu bakuze bafite umubyibuho ukabije nta diyabete, buri cyumweru subataneous retatrutide ibyumweru 48 byakozwekugabanuka, kugabanuka-kugabanuka kuburemere bwumubiri(kugeza ~ 24% bisobanura igihombo kumupanga mwinshi), hamwe no kunoza ibimenyetso byumutima. Gastrointestinal ibibi byabaye kenshi ariko birashobora gucungwa hamwe na titre. Ibyavuye mu cyiciro cya 2 byerekana ko retatrutide ishobora kwerekana igipimo gishya cyo kuvura umubyibuho ukabije, mu gihe hagitegerejwe kwemezwa mu manza nini, z'igihe kirekire.