Retatrutide: Inyenyeri izamuka ishobora guhindura umubyibuho ukabije no kuvura diyabete

Mu myaka yashize, kwiyongera kw'imiti ya GLP-1 nka semaglutide na tirzepatide byagaragaje ko gutakaza ibiro bishoboka bidashoboka kubagwa. Noneho,Retatrutide, triple reseptor agonist yakozwe na Eli Lilly, irimo gukurura isi yose mubuvuzi ndetse nabashoramari kimwe nubushobozi bwayo bwo gutanga ibisubizo byinshi kurushaho binyuze muburyo bwihariye bwibikorwa.

Iterambere ryimikorere myinshi-Intego

Retatrutide iragaragaraicyarimwe gukora icyarimwe cya reseptors eshatu:

• GLP-1- Kurwanya ubushake bwo kurya, kugabanya umuvuduko wa gastrica, no kunoza ururenda rwa insuline

• GIP yakira- Kongera imbaraga za insuline no guhindura glucose metabolism

• Glucagon reseptor- Yongera igipimo fatizo cya metabolike, iteza amavuta kugabanuka, kandi ikongera ingufu zikoreshwa

Ubu buryo "butatu-bukora" ntabwo bushigikira gusa kugabanya ibiro byinshi ahubwo binatezimbere ibintu byinshi byubuzima bwa metabolike, harimo kugenzura glucose, imyirondoro ya lipide, no kugabanya amavuta yumwijima.

Ibisubizo Byambere Byamavuriro Ibisubizo

Mu bigeragezo byambere byubuvuzi, abantu batari diyabete bafite umubyibuho ukabije bafashe Retatrutide mugihe cibyumweru 48 barabonyeimpuzandengo y'ibiro birenga 20%, hamwe nabitabiriye amahugurwa bagera kuri 24% - bemeza imikorere yo kubaga ibibari. Mu bantu barwaye diyabete yo mu bwoko bwa 2, uyu muti ntiwagabanije cyane urwego rwa HbA1c ahubwo wanagaragaje ubushobozi bwo kuzamura ingaruka ziterwa n’umutima n’imitsi.

Amahirwe n'ibibazo biri imbere

Mugihe Retatrutide yerekana amasezerano adasanzwe, iracyari mu cyiciro cya 3 cyamavuriro kandi ntibishoboka ko igera ku isoko mbere2026–2027. Niba koko ishobora guhinduka "umukino-uhindura" bizaterwa na:

1. Umutekano muremure- Gukurikirana ingaruka nshya cyangwa zongerewe ugereranije nibiyobyabwenge bya GLP-1

2. Kwihanganirana no kubahiriza- Kumenya niba efficacy irenze izana ikiguzi cyibiciro byo guhagarika akazi

3. Ubucuruzi bushoboka- Ibiciro, ubwishingizi, no gutandukanya neza ibicuruzwa birushanwe

Ingaruka zishobora kuba ku isoko

Niba Retatrutide ishobora guhuza uburinganire bukwiye hagati yumutekano, gukora neza, no guhendwa, irashobora gushyiraho urwego rushya rwimiti igabanya ibiro kandi igatera umubyibuho ukabije na diyabete mugihe cyigiheintego nyinshi zifatika- birashoboka kuvugurura isoko yose yindwara ya metabolike kwisi yose.