Mu myaka yashize, kuvura umubyibuho ukabije na diyabete yo mu bwoko bwa 2 byateye imbere mu mpinduramatwara. Gukurikira GLP-1 yakira agoniste (urugero, Semaglutide) hamwe na agoniste ebyiri (urugero, Tirzepatide),Retatrutide(LY3437943), atriple agonist(GLP-1, GIP, na glucagon reseptors), yerekanye imikorere itigeze ibaho. Hamwe nibisubizo bitangaje mukugabanya ibiro no kunoza metabolike, bifatwa nkubuvuzi bushobora gutera indwara ziterwa na metabolike.
Uburyo bwibikorwa
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Gukora GLP-1: Yongera imisemburo ya insuline, igabanya ubushake bwo kurya, itinda gusiba gastric.
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GIP yakira: Yongera ingaruka zo kugabanya glucose ya GLP-1, itezimbere insuline.
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Glucagon reseptor: Guteza imbere gukoresha ingufu hamwe no guhinduranya amavuta.
Imikoreshereze yizi reseptors eshatu ituma Retatrutide irenga imiti iriho haba kugabanya ibiro ndetse no kurwanya glycemic.
Ikigeragezo cya Clinical Data (Icyiciro cya II)
Muri aIcyiciro cya II igeragezwa hamwe nabarwayi 338 bafite ibiro byinshi, Retatrutide yerekanye ibisubizo bitanga icyizere cyane.
Imbonerahamwe: Kugereranya Retatrutide na Placebo
| Igipimo (mg / icyumweru) | Kugabanya Ibiro (%) | Kugabanya HbA1c (%) | Ibisanzwe Bibi |
|---|---|---|---|
| 1 mg | -7.2% | -0.9% | Isesemi, kuruka byoroheje |
| 4 mg | -12.9% | -1.5% | Isesemi, kubura ubushake bwo kurya |
| 8 mg | -17.3% | -2.0% | GI kutoroherwa, impiswi yoroheje |
| 12 mg | -24.2% | -2.2% | Isesemi, kubura ubushake bwo kurya, kuribwa mu nda |
| Umwanya | -2.1% | -0.2% | Nta mpinduka zikomeye |
Kwerekana Data (Kugereranya Ibiro)
Imbonerahamwe ikurikira irerekana iimpuzandengo yo kugabanya ibirohejuru ya dosiye zitandukanye za Retatrutide ugereranije na placebo:
Igihe cyo kohereza: Nzeri-16-2025