Retatrutide ihindura uburyo umubyibuho ukabije

Muri iki gihe, umubyibuho ukabije wabaye ikibazo cy’ubuzima ku isi hose, no kuvuka kwaRetatrutideitanga ibyiringiro bishya kubarwayi barwana nuburemere burenze. Retatrutide ni atriple reseptor agonistintegoGLP-1R, GIPR, na GCGR. Ubu buryo budasanzwe bwo guhuza ibikorwa byerekana ubushobozi budasanzwe bwo kugabanya ibiro.

Muburyo bwa tekinike, Retatrutide ikoraGLP-1, iteza imisemburo ya insuline, igabanya irekurwa rya glucagon, ikanadindiza ubusa gastric, bityo bikongera guhaga no kugabanya ibiryo. Igikorwa cyaKwakira GIPirusheho kunoza insuline, igenga metabolisme ya lipide, kandi ikorana na GLP-1 kugirango yongere ingaruka zo kugabanya ibiro. Icyingenzi cyane, ibikorwa byayoglucagon reseptors (GCGR)byongera ingufu zikoreshwa, byongera hepatike gluconeogenezesi, kandi bigabanya ibinure byumwijima-hamwe, izi nzira zigira uruhare runini mu kugabanya ibiro.

Mubigeragezo byamavuriro, ingaruka zo kugabanya ibiro bya Retatrutide zabaye zidasanzwe. Mu byumweru 48 by’icyiciro cya 2 cy’ubuvuzi, abitabiriye amahugurwa bahabwa mg 12 buri cyumweru ya Retatrutide yatakaje ikigereranyo cya24.2% by'uburemere bw'umubiri wabo—Igisubizo kirenze kure imiti myinshi yo kugabanya ibiro kandi yegera imikorere yo kubaga ibibari. Byongeye kandi, kugabanya ibiro bikomeje gutera imbere mugihe; naicyumweru 72, impuzandengo yo kugabanya ibiro yageze hafi28%.

Kurenga ingaruka zikomeye zo kugabanya ibiro, Retatrutide irerekana kandi amasezerano akomeye mugutezimbere ibibazo biterwa n'umubyibuho ukabije. Irashobora kugabanya umuvuduko wamaraso, kunoza imyirondoro ya lipide, kugabanya urugero rwa triglyceride, no gutanga uburinzi bwumutima-kuzanainyungu zuzuye z'ubuzimaku bantu babana n'umubyibuho ukabije.