Kanada Igihe cya 2022-01-21, Rhovac, Isosiyete y'imiti yibanze ku hungamirwanyi, yatangaje ko Porogaramu ya Dirent (No 2710061) ku nkombe za kanseri ya Raptadiya (Cipo). Mbere, Isosiyete yabonye patenti ijyanye na RV001 muri Amerika, Uburayi n'Ubuyapani. Iyi nkunga ya patent izatanga uburinzi bwagutse kuri RV001 mumasoko yingenzi no kuzamura inzitizi zipatage.
Kimwe na Porogaramu yagenwe mbere, iyi patenti ikubiyemo urukingo rwa kanseri ya RV001 hamwe nitandukanije no kwivuza / gukumira Rhoc - kwerekana kanseri ya Rhoc. Muri bo, Rhoc ni antigen-antigen ifitanye isano (Taa) irenze urugero mu bwoko butandukanye bw'akagari. Bimaze gutangwa, patenti izarangira muri 2028-12 kandi iteganijwe ko izamurwa nyuma yo kubona icyemezo cyo kurinda ishuri (CSP).
01 KINLBATODEDE
Onilcatode ninkipu za kanseri zigizwe na immunogenic peptide ikomoka mu muryango wa Ras C (Rhoc), ishobora kugaburira mu mpingane ya Fackune Montanide ISA-51, hamwe n'ibikorwa bishobora kuba imyumbati n'ibikorwa bishobora kuba. Ubuyobozi bwa Subtangane bwindege butera imbaraga z'umuricyubahiro wakiriye gucikamo lymphocy t lymphocyt (CTL) igisubizo kuri selile ya Rhoc, bityo huhira ingirabuzimafatizo.
2020-11, RV001 yahawe inzira yihuse ya FDA.
02 Iburanisha rya Clinical
Muri 2018, icyiciro cy'icyiciro I / IIA Clinical Gredical Clinicacotide yo kuvura kanseri ya prostate, kandi abarwayi 21 bose biyandikishije. Ibisubizo byerekanye ko kurigatantuho byari umutekano kandi wihanganirwa neza. Byongeye kandi, abarwayi bateraniye amahirwe yo kudahungabanya umutekano kandi ararambye nyuma yo kuvurwa. Muri 2021, gukurikiranwa muri 19 muri ayo masomo, nyuma yimyaka itatu ndangije kuvurwa na Rhovac, byerekanaga ko aya masomo yari atarangije metastase iyo ari yo yose cyangwa yahawe ubuvuzi kandi ntaho bingana na antigen (Zaburi (Zaburi (Zab) . Muri ibyo, amasomo 16 nta zerera wa PSsa, kandi amasomo 3 yari afite buhoro buhoro kwamamaza. Zab ni poroteyine ikorwa na glande ya prostate kandi ikoreshwa mugukurikirana iterambere rya kanseri izwi.
Muri 2019, icyiciro cya RV001 cya RV001 (byateganijwe, impumyi ebyiri-zidahumanye) zatangijwe kugirango usuzume imikorere yacyo mu gukumira cyangwa kugabanya iterambere rya kanseri ya metastatike nyuma yo kubagwa / imirasire. Uru rubanza rwa IIB ni incuro mpuzamahanga yo gushaka amasomo mu bihugu 6 by'Uburayi (Danemark, Finlande, Suwede, Ububiligi, Ubudage, n'Ubwongereza) na Amerika. Ikigeragezo cyarangiye kwishora mu kwihangana muri 2021-09, hamwe n'amasomo agera ku 175 kwiyandikisha, kandi azarangira muri 2022h1. Byongeye kandi, rhovac gahunda yo kwiga ubushakashatsi bwibanze bugamije gutanga ibimenyetso byerekana ko kwaguka kwa RV001 mubimenyetso.
Byongeye kandi, Komite ishinzwe gukurikirana umutekano kandi yakoresheje interineti ishinzwe umutekano wa RV001 muri 2021-07, kandi nta kintu kibi cyabonetse gitunguranye, cyahuye n'icyiciro cya I / II ii ii.
Igihe cyagenwe: Gashyantare-17-2022