Iterambere ry'ubushakashatsi rya Opioid buringaniye mu kwemerwa na direka

Nko mumyaka 2021-08-24, Vara Tharice Fafor Pharma yatangaje ko abarwayi ba Kappa opioid (CHD) (bitemejwe na FDA. Biteganijwe ko byatangijwe 2022q1. CARA na VIFOR bashyize umukono ku masezerano yihariye yo gucuruzwa ku bucuruzi bwa Kosoruva ™ muri Amerika kandi yemera kugurisha Korsuva ™ muri Fresenius. Muri bo, Cara na Vifor buri wese afite inyungu 60% na 40% gusangira amafaranga yo kugurisha usibye ubuvuzi bwa Fresenius; Buriwese afite inyungu 50% gusangira yinjiza amafaranga ya Fresenius.

Ckd-ifitanye isano (CKD-AP) ni pririto rusange ibaho hamwe ninsanganyamatsiko nyinshi kandi ubukana bwabarwayi ba CKD burimo dialyse. Prurutus ibaho hafi 60% -70% byabarwayi bahabwa dialyse, muri bo 30% - bigira ingaruka zikomeye ku mibereho (urugero, ubuziranenge bwo gusinzira) kandi bufitanye isano no kwiheba. Nta kuvura neza pruritus ijyanye na CKD mbere, kandi kwemerwa na divisulfalin bifasha gukemura ikibazo kinini cyane cyane. Iri shingiro rishingiye ku bigeragezo bibiri by'imiti ya III muri NDA: Amakuru meza yo muri Karalm-1 na Galbive muri Amerika no mu myitozo yakorewe mu bushakashatsi bwa 32, yerekana ko Kosoluva ™ yihanganira.

Ntabwo hashize kuva kera, inkuru nziza yaturutse mu nyigisho z'ubuvuzi ya divikefalin mu Buyapani: 2022-1-10, CARA yatangaje ko abafatanyabikorwa ba Masuisi yakundaga inshinge ya direlukiya ikoreshwa mu Buyapani mu barwayi ba Hemodialysi. Ibigeragezo bya III III ibyangombwa byibanze. 178 Abarwayi bakiriye ibyumweru 6 bya direka cyangwa ubusho kandi bitabira imyitozo yo kwagura icyumweru 52. Iherezo ryibanze (impinduka muri Prurutus Umubare watanga amanota) na Secondary Isoni (impinduka mu manota ya Sweriti mu itsinda rya divaruruline ugereranije n'itsinda ryabereye kandi barihanganira neza.

Diflikefalin nicyiciro cya opioid buringaniye. Hashingiwe kuri iki kigo cya Peptade cyize ibitabo kuri Opioid buri muri make, maze nvuga muri make ingorane n'ingamba za Opioid buringaniye mu iterambere ry'ibiyobyabwenge, ndetse n'imiterere y'iterambere ry'ibiyobyabwenge.