Intangiriro
Tirzepatide, yakozwe na Eli Lilly, ni imiti ya peptide yerekana ibintu byerekana intambwe ikomeye mu kuvura diyabete yo mu bwoko bwa 2 n'umubyibuho ukabije. Bitandukanye na GLP-1 (glucagon-isa na peptide-1) agoniste, Tirzepatide ikorabyombi GIP (glucose-iterwa na insulinotropic polypeptide)naGLP-1, kuyabona izina rya adual reseptor agonist. Ubu buryo bubiri butuma habaho gukora neza mugutunganya glucose yamaraso no kugabanya ibiro byumubiri, cyane cyane kubarwayi barwaye diyabete yo mu bwoko bwa 2 n'umubyibuho ukabije.
Uburyo bwibikorwa
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GIP yakira: Yongera imisemburo ya insuline kandi itezimbere kwihanganira glucose.
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Gukora GLP-1: Itera kurekura insuline, igabanya glucagon isohoka, kandi igabanya umuvuduko wa gastric.
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Gukorana kabiri: Itanga uburyo bwiza bwo kugenzura glycemic no kugabanya ibiro.
Isesengura ryamakuru
1. Ibigeragezo bya SURPASS (Diyabete yo mu bwoko bwa 2)
Hafi ya byinshiIbizamini bya SURPASS, Tirzepatide yarushije insuline na Semaglutide mubisubizo bya glycemic no kugabanya ibiro.
| Itsinda ry'abarwayi | Dose | Avg. Kugabanuka HbA1c | Avg. Gutakaza ibiro |
|---|---|---|---|
| Ubwoko bwa 2 Diyabete | 5 mg | -2.0% | -7.0 kg |
| Ubwoko bwa 2 Diyabete | 10 mg | -2.2% | -9.5 kg |
| Ubwoko bwa 2 Diyabete | 15 mg | -2.4% | -11.0 kg |
Ugereranije na Semaglutide (mg 1: HbA1c -1.9%, Uburemere -6.0 kg), Tirzepatide yerekanye umusaruro ushimishije haba mu kurwanya glycemic no kugabanya ibiro.
2. Ibigeragezo BIKURIKIRA (Umubyibuho ukabije)
Ku barwayi bafite umubyibuho ukabije badafite diyabete, Tirzepatide yerekanye imbaraga zidasanzwe zo kugabanya ibiro.
| Dose | Avg. Kugabanya ibiro (ibyumweru 72) |
|---|---|
| 5 mg | -15% |
| 10 mg | -20% |
| 15 mg | -22.5% |
➡ Ku murwayi upima kg 100, Tirzepatide ikabije irashobora kugabanya ibiro hafi22.5 kg.
Ibyiza by'ingenzi
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Uburyo bubiri: Kurenga GLP-1 agoniste.
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Ingaruka nziza: Bikora neza mugucunga glycemic no gucunga ibiro.
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Birashoboka: Birakwiye kuri diyabete n'umubyibuho ukabije.
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Ubushobozi bwo kwisoko ryinshi: Kwiyongera gukenera imyanya yo kuvura umubyibuho ukabije Tirzepatide nkumuti uzaza.
Icyerekezo cy'isoko
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Ingano yubunini bwisoko: Muri 2030, isoko ry’ibiyobyabwenge GLP-1 ku isi biteganijwe ko rirengaUSD miliyari 150, hamwe na Tirzepatide birashoboka gufata umugabane wiganje.
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Ahantu nyaburanga: Umunywanyi nyamukuru ni Semaglutide ya Novo Nordisk (Ozempic, Wegovy).
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Ibyiza: Amakuru y’amavuriro yerekana Tirzepatide itanga ibiro byinshi ugereranije na Semaglutide, bishimangira isoko ryayo mu kuvura umubyibuho ukabije.
Igihe cyo kohereza: Nzeri-12-2025