Amavu n'amavuko
Ubuvuzi bushingiye kuri Incretin bumaze igihe kinini buzwiho kunoza byombikugenzura amaraso glucosenakugabanya ibiro. Imiti gakondo ya incretin yibanda cyane cyane kuriGLP-1, mu giheTirzepatideahagarariye igisekuru gishya cya “twincretin”Abakozi - bakorabyombi GIP (glucose-iterwa na insulinotropic polypeptide)naGLP-1reseptors.
Iki gikorwa cyibiri cyerekanwe kongera inyungu za metabolike no guteza imbere kugabanuka cyane ugereranije na GLP-1 agoniste yonyine.
SURMOUNT-1 Igishushanyo cyo Kwiga
SURMOUNT-1yari agutoranya, guhuma-kabiri, icyiciro cya 3 ikigeragezo cyamavuriroyakozwe ku mbuga 119 mu bihugu icyenda.
Abitabiriye amahugurwa barimo abantu bakuru bari:
- Umubyibuho ukabije(BMI ≥ 30), cyangwa
- Umubyibuho ukabije(UN)
Abantu barwaye diyabete, gukoresha ibiyobyabwenge vuba aha, cyangwa kubagwa ibibari mbere.
Abitabiriye amahugurwa bahawe amahirwe yo kwakira inshinge imwe mu cyumweru ya:
- Tirzepatide 5 mg, 10 mg, 15 mg, cyangwa
- Umwanya
Abitabiriye amahugurwa bose bahawe kandi ubuyobozi bwo kubaho:
- A icyuho cya caloric ya 500 kcal / kumunsi
- NiburaIminota 150 yo gukora imyitozo ngororamubiri buri cyumweru
Ubuvuzi bwarakomejeIbyumweru 72, harimo aIcyumweru 20 dose-escalation icyicirohakurikiraho igihe cyo gufata ibyumweru 52.
Incamake y'ibisubizo
Igiteranyo cyaAbitabiriye 2,359bariyandikishije.
Ugereranyije imyaka yariImyaka 44.9, 67.5% bari abagore, hamweuburemere bw'umubiri bwa kg 104.8naBMI ya 38.0.
Kugabanya Kugabanya Ibiro Byumubiri Icyumweru cya 72
| Itsinda rya Dose | % Guhindura ibiro | Kugereranya Guhindura Ibiro (kg) | Igihombo cyinyongera vs Placebo |
|---|---|---|---|
| 5 mg | -15.0% | -16.1 kg | -13.5% |
| 10 mg | -19.5% | -22.2 kg | -18,9% |
| 15 mg | -20.9% | -23,6 kg | -20.1% |
| Umwanya | -3.1% | -2,4 kg | - |
Tirzepatide yageze kuri 15-21% bivuze kugabanya ibiro, kwerekana ingaruka zisobanutse zingaruka.
Ijanisha ryabitabiriye kugera ku ntego yo kugabanya ibiro
| Gutakaza ibiro (%) | 5 mg | 10 mg | 15 mg | Umwanya |
|---|---|---|---|---|
| ≥5% | 85.1% | 88.9% | 90.9% | 34.5% |
| ≥10% | 68.5% | 78.1% | 83.5% | 18.8% |
| ≥15% | 48.0% | 66,6% | 70,6% | 8.8% |
| ≥20% | 30.0% | 50.1% | 56.7% | 3.1% |
| ≥25% | 15.3% | 32.3% | 36.2% | 1.5% |
Kurenga kimwe cya kabiriy'abitabiriye kwakira≥10 mgTirzepatide yagezwehoKugabanuka ibiro 20%, kwegera ingaruka zigaragara hamwe no kubaga ibibari.
Inyungu za Metabolic na Cardiovascular
Ugereranije na placebo, Tirzepatide yateye imbere cyane:
- Umuzenguruko
- Umuvuduko w'amaraso wa sisitemu
- Umwirondoro wa Lipid
- Kwiyiriza ubusa kwa insuline
Mu bitabiriye hamwediyabete, 95.3% basubiye kurwego rusanzwe rwa glucose, ugereranije na61.9%mu itsinda rya placebo - byerekana Tirzepatide ntabwo ifasha kugabanya ibiro gusa ahubwo inatezimbere glucose metabolism.
Umutekano no kwihanganirana
Ingaruka zikunze kugaragara nigastrointestinal, harimoisesemi, impiswi, no kuribwa mu nda, ahanini byoroheje kandi byigihe gito.
Igipimo cyo guhagarika kubera ibintu bibi byari hafi4-7%.
Impfu nke zabaye mugihe cyiburanisha, ahanini zifitanye isanoCOVID-19, kandi ntabwo byari bifitanye isano itaziguye nibiyobyabwenge.
Nta tandukaniro rikomeye ryagaragaye mubibazo bifitanye isano na gallbladder.
Ikiganiro
Guhindura imibereho yonyine (indyo na siporo) mubisanzwe bitanga gusaKugabanuka ibiro 3%, nkuko bigaragara mu itsinda rya placebo.
Ibinyuranye, Tirzepatide ishoboye15-21% kugabanya ibiro byose, aInshuro 5-7 zikomeye.
Ugereranije na:
- Ibiyobyabwenge bigabanya umunwa:mubisanzwe kugera ku gihombo 5-10%
- Kubaga ibibari:kugera> igihombo 20%
Tirzepatide ikuraho itandukaniro riri hagati yubuvuzi bwa farumasi no kubaga - gutangaimbaraga, kutagabanya kugabanya ibiro.
Icy'ingenzi, impungenge zatewe no kwiyongera kwa glucose metabolism ntizagaragaye. Ibinyuranye na byo, Tirzepatide yatezimbere insuline kandi ihindura diyabete ya prediabete mu bitabiriye amahugurwa benshi.
Nyamara, uru rubanza rwagereranije Tirzepatide na placebo - ntabwo ari hamweSemaglutide.
Kugereranya kumutwe-kumutwe birakenewe kugirango umenye umukozi utanga ibiro byinshi.
Umwanzuro
Kubantu bakuru bafite umubyibuho ukabije cyangwa umubyibuho ukabije hamwe nibibazo bifitanye isano, wongeyehorimwe mu cyumweru Tirzepatidekuri gahunda yimibereho yubuzima (indyo + imyitozo) irashobora kuganisha kuri:
- Kugereranya ibiro 15-21%
- Iterambere rikomeye ryimikorere
- Kwihanganirana cyane n'umutekano
Tirzepatide rero yerekana uburyo bwiza kandi bwemewe nubuvuzi bwo gucunga ibiro birambye, bigenzurwa nubuvuzi.
Igihe cyo kohereza: Ukwakira-16-2025