Gutera Tirzepatide ya Diyabete no gutakaza ibiro

Tirzepatide ni igitabo gishya cya glucose iterwa na insulineotropique polypeptide (GIP) na glucagon imeze nka peptide-1 (GLP-1) reseptor agonist yateye imbere. Uburyo bwayo bubiri bugamije kongera imisemburo ya insuline, guhagarika irekurwa rya glucagon, gutinda gusohora gastrica, no kunoza guhaga, bitanga uburyo bunoze bwo kuvura indwara ya diyabete yo mu bwoko bwa 2 (T2DM) n'umubyibuho ukabije.

Ibisubizo by'ingenzi bivuye mu bushakashatsi bwa Clinical

1. Kurwanya Glycemic

Hafi ya byinshiSURPASSicyiciro cya 3 ibizamini byamavuriro, tirzepatide yerekanwekugenzura glycemicugereranije na antidiabete ihari, harimo semaglutide na insuline degludec.

• Kugabanya HbA1c kugabanuka: kugeza kuri.42.4%kuva kuri baseline nyuma yibyumweru 40-52.

• Umubare munini w'abitabiriye amahugurwa bagezwehoHbA1c <6.5%, guhura cyangwa kurenga intego za ADA.

• Iterambere rikomeye mu kwiyiriza plasma glucose no kurwego rwa glucose nyuma yo kugaragara.

Kugabanya ibiro

Tirzepatide yakozwe buri gihemubuvuzi bufite ireme kandi bugabanutse kugabanukamubantu bombi ba diyabete nabatari diyabete.

• Mu barwayi ba T2DM: impuzandengo yo kugabanya ibiro byumubiri kuva7 kg.

• Mu ngingo zifite umubyibuho ukabije utari diyabete (Ikigeragezo cya SURMOUNT-1):

  • 10 mg na 15 mg ya dosiye biganisha kuri15-22% bivuze kugabanya ibiro, bigereranywa cyangwa birenze ibipimo byo kubaga ibibari.

• Abenshi mu bitabiriye amahugurwa bagezeho byibuze5-10%kugabanya ibiro.

3. Kunoza umutima

Kuvura Tirzepatide nabyo byateje imbere ibipimo ngari bya metabolike:

• Kugabanukamuri triglyceride, LDL-C, na cholesterol yuzuye.

• Yiyongeramuri HDL-C.

• Birahambayekugabanuka k'umuvuduko w'amaraso wa sisitemu na diastolique.

• Gutezimbere muburyo bwa insuline no β-selile imikorere.

4. Umutekano no kwihanganirana

Umwirondoro wumutekano wahujwe nubundi buvuzi bushingiye kuri incretin:

• Ibintu byinshi bikunze kubaho bibi: ibimenyetso byigifu byoroheje (isesemi, kuruka, impiswi).

• Indwara nke ya hypoglycemia, cyane iyo ikoreshejwe na insuline cyangwa sulfonylureas.

• Nta mpungenge zikomeye z'umutekano zigaragara mubisubizo byumutima.

5. Ubushishozi

Tirzepatide idasanzwedual reseptor agonismyongerera inzira GIP na GLP-1 inzira:

• Gukora GIPbyongera glucose iterwa na insuline isohoka kandi irashobora kunoza adipose tissue metabolism.

• Gukora GLP-1iteza imbere ubushake bwo kurya no gutinda gusiba gastric.

• IbyaboIngarukabiganisha ku kunoza glucose kugenzura hamwe no kugabanya ibiro ugereranije ninzira imwe.

Umwanzuro

Tirzepatide yerekana aintambwe mu kuvura metabolike, gutangaefficacy itigeze ibaho muburyo bwo kugenzura glycemic no kugabanya ibirokubantu barwaye diyabete yo mu bwoko bwa 2 n'umubyibuho ukabije.
Uburyo bubiri bwa incretin butanga uburyo bukomatanyije bukemura intandaro yo gukora nabi metabolike - hyperglycemia, kurwanya insuline, hamwe nuburemere bwumubiri burenze.
Bitewe nubushobozi bukomeye hamwe numwirondoro wumutekano ushobora gucungwa, tirzepatide irashobora gusobanura paradigima yo kuvura diyabete no gucunga umubyibuho ukabije mumyaka icumi iri imbere.

Reba

• Frias JP n'abandi.,Ikinyamakuru gishya cy’ubuvuzi, 2021.

• Jastreboff AM n'abandi.,Ikinyamakuru gishya cy’ubuvuzi, 2022 (SURMOUNT-1).

• Ludvik B n'abandi.,Lancet, 2021.

• Eli Lilly Amakuru Yubuvuzi, Ibigeragezo bya SURPASS 1-5.