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Izina ryuzuye:Kurinda umubiri-157, apentadecapeptide (peptide 15-amino aside)ubanza bitandukanije numutobe wigifu.
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Urukurikirane rwa aside amine:Gly-Glu-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, uburemere bwa molekile ≈ 1419.55 Da.
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Ugereranije nizindi peptide nyinshi, BPC-157 ihagaze neza mumazi numutobe wigifu, ibyo bigatuma ubuyobozi bwo munwa cyangwa gastrica bushoboka.
Uburyo bwibikorwa
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Angiogenezi / Kugarura kuzenguruka
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KugenzuraVEGFR-2imvugo, iteza imbere imiyoboro mishya y'amaraso.
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GukoraInzira ya Src - Caveolin-1 - eNOS, biganisha kuri aside nitide (OYA) kurekura, vasodilation, no kunoza imikorere yimitsi.
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Kurwanya inflammatory & Antioxidant
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Kugabanya cytokine itera inflammatory nkaIL-6naTNF-α.
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Kugabanya ubwoko bwa ogisijeni ikora (ROS), ikingira selile imbaraga za okiside.
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Gusana imyenda
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Guteza imbere imiterere n'imikorere muburyo bwo gukomeretsa, imitsi, n'imitsi.
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Itanga neuroprotection muburyo bwo gukomeretsa sisitemu yo hagati (compression spinal cord, cerebral ischemia-reperfusion), kugabanya urupfu rwa neuronal no kunoza moteri / ibyiyumvo.
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Kugena amajwi y'amaraso
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Ex vivo vascular studies yerekana BPC-157 itera vasorelaxation, biterwa na endotelium idahwitse kandi NTA nzira.
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Inyamaswa & Muri Vitro Kugereranya Ibyatanzwe
| Ubwoko bw'igerageza | Icyitegererezo / Gutabara | Igipimo / Ubuyobozi | Kugenzura | Ibisubizo by'ingenzi | Kugereranya Amakuru |
|---|---|---|---|---|---|
| Vasodilation (imbeba aorta, ex vivo) | Fenilephrine-yasezeranijwe impeta ya aortic | BPC-157 kugeza kuri100 μg / ml | Nta BPC-157 | Vasorelaxation ~37.6 ± 5.7% | Kugabanuka Kuri10.0 ± 5.1% / 12.3 ± 2,3%hamwe na NOS inhibitor (L-IZINA) cyangwa OYA scavenger (Hb) |
| Endothelial selile assay (HUVEC) | Umuco wa HUVEC | 1 μg / ml | Igenzura ritavuwe | ↑ NTA musaruro (Inshuro 1.35); Kwimuka kwimuka | Kwimuka byavanyweho Hb |
| Ischemic limb model (imbeba) | Hindlimb ischemia | 10 μg / kg / umunsi (ip) | Nta muti | Amaraso yihuta gukira, ↑ angiogenez | Umuti> Igenzura |
| Gucisha umugongo (imbeba) | Sakrococcygeal umugongo kwikuramo | Gutera inshinge imwe min 10 min nyuma yimvune | Itsinda ritavuwe | Kugarura gukomeye kwimitsi nuburyo byubaka | Itsinda rishinzwe kugenzura ryakomeje kuba ikimuga |
| Icyitegererezo cya Hepatotoxicity (CCl₄ / inzoga) | Gukomeretsa umwijima | 1 µg cyangwa 10 ng / kg (ip / umunwa) | Kutavurwa | AST / ALT, yagabanije necrosis | Itsinda rishinzwe kugenzura ryerekanye igikomere gikomeye cyumwijima |
| Kwiga uburozi | Imbeba, inkwavu, imbwa | Ingano nyinshi / inzira | Igenzura rya Placebo | Nta burozi bukomeye, nta LD₅₀ yagaragaye | Wihanganirwa neza no kuri dosiye nyinshi |
Ubushakashatsi bwabantu
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Urukurikirane rw'imanza: Gutera inshinge za BPC-157 ku barwayi 12 bafite ububabare bwo mu ivi → 11 bavuze ko ububabare bukomeye. Imipaka: nta tsinda rishinzwe kugenzura, nta guhuma, ibisubizo bifatika.
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Ikigeragezo cya Clinical: Icyiciro cya mbere cy’umutekano n’ubushakashatsi bwa farumasi (NCT02637284) mu bakorerabushake 42 bafite ubuzima bwiza bwakozwe, ariko ibisubizo ntibitangazwa.
Kugeza ubu,nta bigeragezo byujuje ubuziranenge byateganijwe (RCTs)zirahari kugirango zemeze imikorere yubuvuzi n'umutekano.
Umutekano & Ingaruka zishobora kubaho
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Angiogenez: Ifite akamaro ko gukira, ariko irashobora guteza imbere kubyimba imitsi yibibyimba, kwihuta gukura cyangwa metastasis kubarwayi ba kanseri.
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Dose & Ubuyobozi: Bikora neza mubikoko kumupanga muke cyane (ng - µg / kg), ariko ibipimo byiza byabantu ninzira bikomeza kutamenyekana.
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Gukoresha igihe kirekire: Nta makuru yuzuye yuburozi yigihe kirekire; ubushakashatsi bwinshi ni igihe gito.
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Imiterere: Ntabwo byemewe nk'ibiyobyabwenge mu bihugu byinshi; yashyizwe mu rwego rwa aibintu bibujijwena WADA (Ikigo gishinzwe kurwanya ibiyobyabwenge).
Kugereranya Ubushishozi & Imipaka
| Kugereranya | Imbaraga | Imipaka |
|---|---|---|
| Inyamaswa vs Umuntu | Ingaruka zingirakamaro zi nyamaswa (tendon, nerv, gusana umwijima, angiogenez) | Ibimenyetso byabantu ni bike, ntibigenzurwa, kandi ntibikurikiranwa igihe kirekire |
| Urwego | Ikora kuri dosiye nkeya cyane mubikoko (ng - µg / kg; µg / ml muri vitro) | Umutekano / ingirakamaro kumuntu utazwi |
| Gutangira ibikorwa | Ubuyobozi bwambere nyuma yimvune (urugero, iminota 10 nyuma yimvune yumugongo) butanga gukira gukomeye | Ivuriro rishoboka ryigihe ntigisobanutse |
| Uburozi | Nta miti yica cyangwa ingaruka mbi zigaragara mu moko menshi yinyamaswa | Uburozi bwigihe kirekire, kanseri, numutekano wimyororokere bikomeje kutageragezwa |
Umwanzuro
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BPC-157 yerekana ingaruka zikomeye zo kuvugurura no gukingira muburyo bw'inyamaswa n'ingirabuzimafatizo: angiogenez, anti-inflammation, gusana ingirangingo, neuroprotection, na hepatoprotection.
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Ibimenyetso byabantu ni bike cyane, nta makuru akomeye yubuvuzi aboneka.
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Ibindibyateguwe neza ibigeragezo byateganijwebasabwa gushiraho imikorere, umutekano, kunywa neza, ninzira zubutegetsi mubantu.
Igihe cyo kohereza: Nzeri-23-2025