Mounjaro (Tirzepatide) ni iki?

Mounjaro (Tirzepatide) numuti wo kugabanya ibiro no kubungabunga urimo ibintu bikora tirzepatide. Tirzepatide nigihe kirekire gikora GIP na GLP-1 reseptor agonist. Ibyo byakira byombi biboneka muri alpha pancreatic alpha na beta endocrine selile, umutima, imiyoboro y'amaraso, selile immunite (leukocytes), amara n'impyiko. GIP yakira nayo iboneka muri adipocytes.
Byongeye kandi, byombi byakira GIP na GLP-1 bigaragarira mubice byubwonko bifite akamaro mukugenzura ibyifuzo. Tirzepatide iratoranya cyane kubantu bakira GIP na GLP-1. Tirzepatide ifitanye isano ryinshi ryakira GIP na GLP-1. Igikorwa cya tirzepatide kuri reseptor ya GIP isa niy'imisemburo isanzwe ya GIP. Igikorwa cya tirzepatide kuri reseptor ya GLP-1 kiri munsi yicy'imisemburo isanzwe ya GLP-1.
Mounjaro (Tirzepatide) ikora ikora kuri reseptors yo mu bwonko igenzura ubushake bwo kurya, bigatuma wumva wuzuye, ushonje, kandi udashobora kwifuza ibiryo. Ibi bizagufasha kurya bike no kugabanya ibiro.
Mounjaro igomba gukoreshwa hamwe na gahunda yo kugaburira-calorie no kongera imyitozo ngororamubiri.

Ibipimo birimo

Mounjaro (Tirzepatide) yerekanwa mu gucunga ibiro, harimo kugabanya ibiro no kubungabunga, nk'umugereka w'imirire yagabanijwe na calorie ndetse no kongera imyitozo ngororamubiri ku bantu bakuru bafite icyerekezo rusange cy'umubiri (BMI) cya:
≥ 30 kg / m2 (umubyibuho ukabije), cyangwa
≥ 27 kg / m2 kugeza kuri <30 kg / m2 (umubyibuho ukabije) ufite byibura ingaruka ziterwa n'uburemere nka dysglycemia (diyabete ya prediabete cyangwa diyabete yo mu bwoko bwa 2), hypertension, dyslipidemia, cyangwa gusinzira inzitizi apnea Kwemera kuvura no kubahiriza ibiryo bihagije.
Imyaka 18-75
Niba umurwayi ananiwe gutakaza byibuze 5% yuburemere bwumubiri wambere nyuma y amezi 6 yo kuvurwa, hagomba gufatwa icyemezo cyo gukomeza kwivuza, hitabwa ku nyungu / ingaruka z’umurwayi ku giti cye.

Ingengabihe

Igipimo cyo gutangira cya tirzepatide ni 2,5 mg rimwe mu cyumweru. Nyuma yibyumweru 4, ikinini kigomba kongerwa kugeza kuri mg 5 rimwe mucyumweru. Niba bikenewe, ikinini gishobora kwiyongeraho mg 2,5 byibura ibyumweru 4 hejuru yikigero kiriho.
Ibyifuzo byo kubungabunga ni 5, 10, na 15 mg.
Igipimo ntarengwa ni 15 mg rimwe mu cyumweru.

Uburyo bwo gufata

Mounjaro (Tirzepatide) irashobora gutangwa rimwe mu cyumweru igihe icyo aricyo cyose cyumunsi, hamwe nibiryo.
Igomba guterwa mu buryo bwihuse mu nda, ikibero, cyangwa ukuboko hejuru. Ikibanza cyo gutera inshinge kirashobora guhinduka. Ntigomba guterwa inshinge cyangwa imitsi.
Niba bikenewe, umunsi wo gufata icyumweru urashobora guhinduka mugihe igihe kiri hagati ya dosiye byibuze iminsi 3 (> amasaha 72). Umunsi mushya wo gukuramo watoranijwe, kunywa bigomba gukomeza rimwe mubyumweru.
Abarwayi bagomba gusabwa gusoma amabwiriza yo gukoresha muri paki winjizamo neza mbere yo gufata imiti.