PT-141 ni iki?

Kwerekana (gukoresha byemewe): Muri 2019, FDA yemeje ko ivura indwara ya hypoactive hypoactive yifuza guhuza ibitsina (HSDD) ku bagore batwite igihe iyo ndwara itera umubabaro ugaragara kandi ntibiterwa nizindi ndwara zubuvuzi / uburwayi bwo mu mutwe cyangwa ingaruka mbi zibiyobyabwenge.

Uburyo bwibikorwa
PT-141 ni reseptor ya melanocortin agonist (cyane cyane reseptor ya MC4) ihindura irari ry'ibitsina binyuze mumihanda ya nervice yo hagati.

Bitandukanye na PDE5 inhibitor (urugero, sildenafil), yibasira cyane cyane imiyoboro y'amaraso, PT-141 ikora hagati kugirango igire ingaruka ku mibonano mpuzabitsina no kubyutsa.

Pharmacology & Dose
Ubuyobozi: Gutera inshinge, nkuko bikenewe (kubisabwa).
Igipimo cyemewe: 1.75 mg sc

Imiti ya farumasi:
Tmax ≈ ~ iminota 60
t½ ≈ amasaha 2-3
Ingaruka zirashobora kumara amasaha menshi, muri raporo zimwe kugeza ~ amasaha 16.
Ingaruka zamavuriro (Ikigeragezo cyicyiciro cya III - KUMENYA, ibyumweru 24, RCTs)

Intangiriro y'ibanze:
Igipimo Cyimikorere Y Igitsina Cyumugore - Icyifuzo (FSFI-D)
Igipimo Cy’imibonano mpuzabitsina ku bagore (FSDS-DAO)
Ibisubizo by'ingenzi (ubushakashatsi bwahujwe 301 + 302):
Gutezimbere kwa FSFI-D: +0.35 vs umwanya (P <0.001)
Kugabanya amanota ya FSDS-DAO: −0.33 vs umwanya wa (P <0.001)
Izindi ngingo zanyuma: Ibisubizo byunganira (amanota yimikorere yimibonano mpuzabitsina, abarwayi bavuga ko banyuzwe) byagaragaye ko ari byiza, ariko ibintu byimibonano mpuzabitsina bishimishije (SSEs) ntabwo byerekanaga buri gihe itandukaniro rikomeye.

Ibintu bibi (bikunze kuvugwa mubigeragezo)
Bisanzwe (≥10%):
Isesemi (~ 30-40%; kugeza ~ 40% byavuzwe mubigeragezo)
Kuzunguruka (≥10%)
Kubabara umutwe (≥10%)

Ingaruka z'umutima n'imitsi:
Ubwiyongere bwigihe gito bwumuvuduko wamaraso hamwe nimpinduka zumutima byagaragaye, mubisanzwe bikemuka mumasaha make.
Yanduye cyangwa ikoreshwa mubwitonzi kubarwayi bafite hypertension itagenzuwe cyangwa indwara z'umutima.
Umwijima: Raporo zidasanzwe zerekana inzitizi zumwijima zinzibacyuho; Raporo zidasanzwe cyane zerekana ko bishoboka gukomeretsa umwijima, ariko ntibisanzwe.

Umutekano muremure (Kwagura Kwagura)
Icyumweru 52 cyafunguye-label yo kwagura ubushakashatsi bwagaragaje iterambere rirambye mubyifuzo nta kimenyetso gishya cyumutekano.
Umwirondoro wigihe kirekire wumutekano ufatwa muri rusange wihanganirwa neza, hamwe nibibazo nyamukuru byihanganirwa biracyari ingaruka zigihe gito nko kugira isesemi.

Ingingo z'ingenzi zikoreshwa
Umubare w'abaturage bemewe ni muto: Gusa kubagore batwite bafite HSDD yabonetse, rusange.
Ntabwo byemewe cyane kubagabo (ED cyangwa ubushake buke kubagabo bikomeza iperereza).
Gusuzuma umutekano ni ngombwa: Umuvuduko ukabije w'amaraso, indwara z'umutima n'imitsi, n'amateka y'umwijima bigomba gusuzumwa mbere yo kubitanga.

Incamake yamakuru
Icyemezo cya FDA: 2019 (Vyleesi).
Igipimo: 1.75 mg inshinge zo munsi, kubisabwa.
PK: Tmax ~ 60 min; t½ 2–3 h; ingaruka kugeza ~ 16 h.
Ingaruka (Icyiciro cya III, cyahujwe):
FSFI-D: +0.35 (P <.001)
FSDS-DAO: −0.33 (P <.001)

Ibintu bibi:
Isesemi: kugeza ~ 40%
Flushing: ≥10%
Kubabara umutwe: ≥10%
Inzibacyuho BP yiyongera byagaragaye.

Kugereranya Imbonerahamwe & Igishushanyo (Incamake)