Plozasiran

Plozasiran (API)

Gusaba Ubushakashatsi:
Plozasiran API ni sintetike ntoya yivanga RNA (siRNA) yatejwe imbere yo kuvura hypertriglyceridemia hamwe nindwara zifata umutima nimiyoboro hamwe na metabolike. Ireba iAPOC3gene, igizwe na apolipoprotein C-III, igenga urufunguzo rwa metabolism ya triglyceride. Mu bushakashatsi, Plozasiran akoreshwa mu kwiga ingamba zo kugabanya lipide zishingiye kuri RNAi, gucecekesha gene, no kuvura igihe kirekire ku bihe nka syndrome de famille chylomicronemia (FCS) hamwe na dyslipidemiya ivanze.

Imikorere:
Plozasiran imikorere mukicecekeraAPOC3mRNA mu mwijima, biganisha ku kugabanuka kwa apolipoproteine ​​C-III. Ibi biteza imbere lipolysis no gukuraho lipoproteine ​​ikungahaye kuri triglyceride ikomoka mumaraso. Nka API, Plozasiran ituma habaho iterambere ryigihe kirekire rigamije kugabanya cyane urugero rwa triglyceride no kugabanya ibyago byo kwandura pancreatite nibibazo byumutima nimiyoboro yumutima kubarwayi bafite lipide ikomeye cyangwa genetique.