Ibicuruzwa
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Givosiran
Givosiran API ni sintetike ntoya yivanga RNA (siRNA) yize kugirango ivure poropiya ikaze ya hepatike (AHP). Irasa cyane cyane iALAS1gene (aminolevulinic acide synthase 1), igira uruhare munzira ya heme biosynthesis. Abashakashatsi bifashisha Givosiran kugira ngo bakore iperereza ku buvuzi bwa RNA (RNAi) bushingiye ku buvuzi, gucecekesha gene igamije umwijima, no guhindura inzira za metabolike zigira uruhare muri porphiriya n'indwara zishingiye ku ngirabuzima fatizo.
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Pegcetacoplan
Pegcetacoplan ni peptide ya pigisile ya piside ikora nka inhibitor ya C3 yuzuzanya, yateguwe mu kuvura indwara zuzuzanya nka paroxysmal nocturnal hemoglobinuria (PNH) hamwe na geografiya ya GA (GA) mugihe cyo guta imyaka.
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Plozasiran
Plozasiran API ni sintetike ntoya yivanga RNA (siRNA) yatejwe imbere yo kuvura hypertriglyceridemia hamwe nindwara zifata umutima nimiyoboro hamwe na metabolike. Ireba iAPOC3gene, igizwe na apolipoprotein C-III, igenga urufunguzo rwa metabolism ya triglyceride. Mu bushakashatsi, Plozasiran akoreshwa mu kwiga ingamba zo kugabanya lipide zishingiye kuri RNAi, gucecekesha gene, no kuvura igihe kirekire ku bihe nka syndrome de famille chylomicronemia (FCS) hamwe na dyslipidemiya ivanze.
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Zilebesiran
Zilebesiran API ni iperereza rito ryivanga RNA (siRNA) ryakozwe kugirango rivure hypertension. Ireba iAGTgene, igizwe na angiotensinogen-igice cyingenzi cya sisitemu ya renin-angiotensin-aldosterone (RAAS). Mu bushakashatsi, Zilebesiran akoreshwa mu kwiga uburyo bwo gucecekesha gene mu gihe cyo kurwanya umuvuduko w’amaraso igihe kirekire, tekinoroji yo gutanga RNAi, n’uruhare runini rw’inzira ya RAAS mu ndwara zifata umutima ndetse n’impyiko.
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Palopegteriparatide
Palopegteriparatide ni parathiyide ikora imisemburo miremire ya reseptor agonist (PTH1R agonist), yatunganijwe mu kuvura hypoparathiyide idakira. Nibigereranirizo bya PTH (1-34) byashizweho kugirango bitange calcium ihoraho hamwe no kunywa rimwe mu cyumweru.
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GHRP-6
GHRP-6.
Ibiranga API:
Isuku ≥99%
Yakozwe hifashishijwe synthesis ikomeye ya peptide (SPPS)
Yatanzwe kuri R&D no gukoresha ubucuruzi
GHRP-6 ni peptide yubushakashatsi butandukanye kugirango ifashe metabolike, kuvugurura imitsi, no guhindura imisemburo.
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GHRP-2
GHRP-2 (Gukura Hormone Kurekura Peptide-2) ni sintetike ya hexapeptide hamwe na hormone ikura ikomeye ya hormone secretagogue, igamije gushimangira irekurwa risanzwe ryimisemburo ikura (GH) mugukoresha reseptor ya GHSR-1a muri hypothalamus na pitoito.
Ibiranga API:
Isuku ≥99%
Biraboneka kuri R&D nibitangwa mubucuruzi, hamwe na QC yuzuye
GHRP-2 ni peptide yubushakashatsi bwingirakamaro mubijyanye na endocrinology, ubuvuzi bushya, hamwe nubuvuzi bujyanye n'imyaka.
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Hexarelin
Hexarelin ni imisemburo ikura ya hormone secretagogue peptide (GHS) hamwe na GHSR-1a agonist ikomeye, yakozwe kugirango itume imisemburo ikura ya endogenous ikura (GH). Ni iy'umuryango wigana ghrelin kandi igizwe na acide esheshatu za amine (hexapeptide), itanga imbaraga zo guhinduranya metabolike hamwe ningaruka zikomeye zo kurekura GH ugereranije n’ibigereranyo byabanje nka GHRP-6.
Ibiranga API:
Isuku ≥ 99%
Yakozwe hifashishijwe synthesis ya peptide ikomeye (SPPS)
Ibipimo bisa na GMP, endotoxine nkeya nibisigara bya solvent
Isoko ryoroshye: R&D kurwego rwubucuruzi
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Melanotan II
Ibiranga API:
Isuku ryinshi ≥ 99%
Synthesize ikoresheje synthesis ya peptide ikomeye (SPPS)
Endotoxine nkeya, ibisigara bike bisigaye
Kuboneka muri R&D kurwego rwubucuruzi -
Melanotan 1
Melanotan 1 API ikorwa hifashishijwe tekinoroji ikomeye ya peptide synthesis (SPPS) muburyo bukomeye bwo kugenzura ubuziranenge bwa GMP.
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Isuku ryinshi ≥99%
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Synthesis ikomeye ya peptide ikomeye (SPPS)
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GMP isa ninganda zikora
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Inyandiko zuzuye: COA, MSDS, amakuru ahamye
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Isoko rinini: R&D kurwego rwubucuruzi
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MOTS-C
MOTS-C API ikorwa muburyo bukomeye bwa GMP ikoresheje tekinoroji ya peptide synthesis (SPPS) kugirango ireme neza, isukuye ryinshi kandi ihamye cyane mubushakashatsi no gukoresha imiti.
Ibiranga ibicuruzwa:Isuku ≥ 99% (byemejwe na HPLC na LC-MS),
Endotoxine nkeya nibisigara bisigaye,
Yakozwe ukurikije ICH Q7 na GMP isa na protocole,
Irashobora kugera ku musaruro munini, uhereye kuri miligarama yo mu rwego rwa R&D kugeza kuri garama-urwego na kilo yo mu rwego rwo gutanga ibicuruzwa. -
Ipamorelin
Ipamorelin API yateguwe na progaramu yo mu rwego rwo hejuru ** ikomeye ya peptide synthesis (SPPS) ** kandi ikorerwa isuku rikomeye kandi ikageragezwa ubuziranenge, ikwiriye gukoreshwa hakiri kare imiyoboro yubushakashatsi niterambere nisosiyete ikora imiti.
Ibicuruzwa birimo:
Isuku ≥99% (ikizamini cya HPLC)
Nta endotoxine, ibisigara bike bisigaye, ibyuma bike ion yanduye
Tanga urutonde rwuzuye rwinyandiko zujuje ubuziranenge: COA, raporo yo kwiga ituze, isesengura ryanduye, nibindi.
Guhindura gram-urwego ~ kilo-urwego rwo gutanga