REVERSE T3 ya synthesis ya protein, thermoregulation, kubyara ingufu no kugenzura
Ibicuruzwa birambuye
| Izina | REVERSE T3 |
| Numero ya CAS | 5817-39-0 |
| Inzira ya molekulari | C15H12I3NO4 |
| Uburemere bwa molekile | 650.97 |
| Ingingo yo gushonga | 234-238 ° C. |
| Ingingo yo guteka | 534.6 ± 50.0 ° C. |
| Isuku | 98% |
| Ububiko | Bika ahantu hijimye, Bifunze byumye, Ubike muri firigo, munsi ya -20 ° C. |
| Ifishi | Ifu |
| Ibara | Ibara ryijimye |
| Gupakira | Umufuka wa PE + Aluminium |
Synonyme
ReverseT3 (3,3 ', 5'-Triiodo-L-Thyronine); L-Tyrosine, O- (4-hydroxy-3,5-diiodophenyl) -3-iodo -; (2S) -2-aMino-3- [4- (4-hydroxy-3,5-diiodophe) noxy) -3-iodophenyl] propanoicacid; REVERSET3; T3; LIOTHYRONIN; L-3,3 ', 5'-TRIIODOTHYRONINE; 3,3 ′, 5′-Triiodo-L-thyronine (ReverseT3) igisubizo
Ingaruka ya Farumasi
Ibisobanuro
Tlande ya tiroyide ni glande nini ya endocrine nini mu mubiri w'umuntu, kandi ibintu by'ingenzi bikora ni tetraiodothyronine (T4) na triiodothyronine (T3), bifite akamaro kanini cyane mu gusanisha poroteyine, kugenzura ubushyuhe bw'umubiri, kubyara ingufu no kugira uruhare mu kugenzura. Hafi ya T3 muri serumu ihindurwa kuva periferique tissue deiodination, naho agace gato ka T3 kasohorwa na tiroyide hanyuma ikarekurwa mumaraso. Hafi ya T3 muri serumu igomba guhuza poroteyine, hafi 90% muri zo zikaba zifitanye isano na globuline ya tiroxine (TBG), igisigaye kikaba kijyanye na albumin, naho umubare muto cyane ugahuzwa na prealbumin ya tiroxine (TBPA). Ibiri muri T3 muri serumu ni 1 / 80-1 / 50 bya T4, ariko ibikorwa byibinyabuzima bya T3 bikubye inshuro 5-10 ibyo T4. T3 igira uruhare runini mugucira urubanza imiterere yumubiri wumuntu, kubwibyo rero ni ngombwa cyane kumenya ibiri muri T3 muri serumu.
Akamaro ka Clinical
Kugena triiodothyronine ni kimwe mu bipimo byerekana gusuzuma indwara ya hyperthyroidism. Iyo hyperthyroidism yiyongereye, nayo ibanziriza kugaruka kwa hyperthyroidism. Byongeye kandi, biziyongera kandi mugihe cyo gutwita na hepatite ikaze. Hypothyroidism, goiter yoroshye, nephritis ikaze na karande, hepatite idakira, cirrhose yumwijima yagabanutse. Ubwinshi bwa Serum T3 bugaragaza imikorere ya glande ya tiroyide ku ngingo zikikije aho kuba ibanga rya glande ya tiroyide. Kwiyemeza T3 birashobora gukoreshwa mugupima T3-hyperthyroidism, kumenya hyperthyroidism hakiri kare no gusuzuma pseudothyrotoxicose. Urwego rwose rwa serumu T3 murwego rusanzwe ruhuza nimpinduka za T4. Nikimenyetso cyoroshye cyo gusuzuma imikorere ya tiroyide, cyane cyane mugupima hakiri kare. Nikimenyetso cyihariye cyo gusuzuma kuri T3 hyperthyroidism, ariko ntigifite agaciro gake mugupima imikorere ya tiroyide. Ku barwayi bavuwe n'imiti ya tiroyide, igomba guhuzwa na tiroxine yose (TT4) kandi, nibiba ngombwa, thyrotropine (TSH) icyarimwe kugirango ifashe kumenya imikorere ya tiroyide.
