Semaglutide
Semaglutide API
Semaglutide ni synthique ndende ikora glucagon imeze nka peptide-1 (GLP-1) reseptor agonist, yakozwe kugirango ivure diyabete yo mu bwoko bwa 2 mellitus n'umubyibuho ukabije. Yahinduwe muburyo bwo kurwanya iyangirika ryimisemburo no kuzamura igice cyubuzima, Semaglutide itanga uburyo bworoshye bwo kunywa inshuro imwe mucyumweru, bikanoza cyane kubahiriza abarwayi.
IwacuSemaglutide APIikorwa hakoreshejwe uburyo bwuzuye, ikuraho ingaruka zijyanye na sisitemu yo kwerekana ibinyabuzima, nka poroteyine yakira cyangwa ADN yanduye. Ibikorwa byose byakozwe byateguwe kandi byemezwa ku gipimo cya kilo, byujuje ibyangombwa bisabwa byujuje ubuziranenge byagaragajwe mu buyobozi bwa FDA bwo mu 2021 ku byerekeranye na ANDA ku miti ya peptide yangiza cyane.
Uburyo bwibikorwa
Semaglutide yigana umuntu GLP-1, imisemburo ya incretin igira uruhare runini muri glucose metabolism. Ikora binyuze muburyo butandukanye bwo guhuza:
-
Bitera gusohora insulinemuburyo bwa glucose
-
Kurwanya gusohora glucagon, kugabanya umwijima wa glucose
-
Gutinda gusiba gastric, biganisha ku kunoza igenzura rya glycemic
-
Kugabanya ubushake bwo kurya no gufata ingufu, gushyigikira kugabanya ibiro
Ibisubizo bya Clinical
Ubushakashatsi bunini bwamavuriro (urugero, ibigeragezo BIKOMEYE NINTAMBWE) byagaragaje ko Semaglutide:
-
Kugabanya cyane HbA1c no kwiyiriza ubusa plasma glucose mubarwayi ba diyabete yo mu bwoko bwa 2
-
Guteza imbere kugabanya ibiro byinshi kandi birambye kubantu bafite ibiro byinshi cyangwa babyibushye
-
Kugabanya ibimenyetso byumutima nimiyoboro yumutima nkumuvuduko wamaraso no gutwika
Hamwe numwirondoro mwiza wumutekano hamwe ninyungu nini zo guhinduranya, Semaglutide yabaye umurongo wa mbere GLP-1 RA muri diyabete no kuvura umubyibuho ukabije. Verisiyo yacu ya API ikomeza ubudahemuka bwimiterere nuburinganire buke (≤0.1% umwanda utazwi na HPLC), byemeza neza ibya farumasi.
