Tirzepatide Lyophilize Yera Yuzuye 99% Ifu ya Peptide 60mg kuri vial kuri diyabete no kugabanya ibiro
Ibicuruzwa birambuye
| Izina | Ifu ya Tirzepatide |
| Isuku | 99% |
| Kugaragara | Ifu yera ya Lyofilize |
| Ubuyobozi | Gutera inshinge |
| Ingano | 10mg, 15mg, 20mg, 30mg, 60mg |
| Amazi | 3.0% |
| Inyungu | Kuvura Diyabete, Gutakaza ibiro |
Ibisobanuro
Tirzepatide Ifu ya Lyofilize (60 mg)
Tirzepatide (LY3298176) niyambere ya agonist ikora ya kabiri yibasira GIP (glucose iterwa na insulineotropique polypeptide) na GLP-1 (glucagon isa na peptide-1). Yakiriye muri Amerika FDA muri Gicurasi 2022 yo kuvura indwara ya diyabete yo mu bwoko bwa 2 (T2DM) nk'umugereka w'imirire no gukora siporo.
Iki gicuruzwa gitangwa nka 60mg ya lyofilize (gukonjesha-yumye) ifu ya sterile mumashanyarazi, igomba kongera guhindurwa namazi ya bagiteri mbere yubuyobozi. Ugereranije na GLP-1 yakira reseptor agonist nka semaglutide cyangwa dulaglutide, tirzepatide yerekana imbaraga nziza mugutezimbere glucose yamaraso, kongera insuline, no gushyigikira kugabanya ibiro. Izi nyungu ziterwa nuburyo bubiri-bwakira uburyo bwo guhuza ibikorwa.
Inyungu z'ingenzi
Kurwanya Glycemic
- Bitera gusohora insuline muburyo bwa glucose
- Kugabanya ururenda rwa glucagon, bigabanya neza glucose yamaraso
- Kwigana ingaruka ziterwa na metabolike ya GIP na GLP-1
Gucunga ibiro
- Guteza imbere guhaga no kugabanya intungamubiri
- Yerekanye gutakaza ibiro byinshi kandi birambye mubushakashatsi bwubuvuzi
Ubuzima bwumutima
- Amakuru yambere yerekana ingaruka zishobora kugabanuka kumutima nimiyoboro yabarwayi bafite T2DM
Imikoreshereze n'imikoreshereze
- Ifu ya Tirzepatide lyofilize (mg 60) igomba guhindurwa namazi ya bagiteri mbere yo kuyakoresha. Ubuyobozi nugutera inshinge, mubisanzwe rimwe mubyumweru kumunsi umwe buri cyumweru.
Ubwoko bwa 2 Diyabete
- Gutangira Dose: 2,5 mg rimwe mu cyumweru
- Titration: Ongera buri byumweru 4 nkuko byihanganirwa
- (→ 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg → 20 mg → 30 mg → 45 mg → kugeza kuri 60 mg)
- Igipimo rusange: 10-30 mg buri cyumweru
- Igipimo ntarengwa: 60 mg buri cyumweru
Umubyibuho ukabije / Gucunga ibiro
- Gutangira Dose: 2,5 mg rimwe mu cyumweru
- Titration: Kwiyongera gahoro gahoro nkuko byihanganirwa
- (2.5 → 5 → 7.5 → 10 → 12.5 → 15 → 20 → 30 → 45 → 60 mg)
- Igipimo rusange: 30-60 mg buri cyumweru
- Igipimo ntarengwa: 60 mg buri cyumweru
Basabwe Kugereranya Ingano
| Kwerekana | Gutangira | Ingengabihe | Igipimo rusange | Umubare ntarengwa | Inshuro |
|---|---|---|---|---|---|
| Ubwoko bwa 2 Diyabete | 2.5 mg buri cyumweru | Ongera buri byumweru 4 (→ 5 → 7.5 → 10 → 12.5 → 15 → 20 → 30 → 45 → 60) | 10-30 mg buri cyumweru | 60 mg buri cyumweru | Rimwe mu cyumweru |
| Umubyibuho ukabije / Gutakaza ibiro | 2.5 mg buri cyumweru | Ongera ushingiye ku kwihanganira (2.5 → 5 → 7.5 → 10 → 12.5 → 15 → 20 → 30 → 45 → 60) | 30-60 mg buri cyumweru | 60 mg buri cyumweru | Rimwe mu cyumweru |
Icyitonderwa:Menya neza ko buri kigero cyabanjirije kwihanganira mbere yo kuzamuka.
Birashoboka Ingaruka mbi
- Gastrointestinal: Isesemi, kuruka, impiswi, no kubura inda (mubisanzwe mugihe cyo gutangira)
- Hypoglycemia: Mubisanzwe ibyago bike, ariko byiyongera iyo uhujwe nindi miti igabanya ubukana
- Urubuga rwo gutera inshinge: Umutuku, guhinda, kubyimba, cyangwa ububabare bworoheje kurubuga
- Pancreatitis: Ntibisanzwe ariko birashoboka; gukurikirana ububabare bwinda bwinda
- Ingaruka zimpyiko: Gukurikirana imikorere yimpyiko birashobora gukenerwa kubantu bamwe
Imiti ya farumasi
- Igice cya kabiri cyubuzima: Hafi icyumweru 1
- Gukoresha inshuro: Gushyigikira byoroshye ubuyobozi rimwe-buri cyumweru
Incamake
Tirzepatide 60 mg ifu ya lyofilize yerekana igisekuru kizaza cyo kuvura, guhuza imbaraga zikomeye za glycemic hamwe no kugabanya ibiro bidasanzwe hamwe no kurinda umutima-mitsi.
Hamwe na gahunda yo gutondekanya buhoro buhoro (2,5 mg → kugeza kuri mg 60), itanga uburyo bwo kwihanganira no guhinduka kwa buri muntu ku giti cye. Ubuyobozi bwayo rimwe mucyumweru butezimbere kubahiriza, bukaba uburyo bushya kandi bunoze bwo gucunga diyabete yo mu bwoko bwa 2 n'umubyibuho ukabije mubuvuzi bugezweho ndetse nubushakashatsi.
