BPC-157

BPC-157 API

BPC-157 (izina ryuzuye: Kurinda umubiri 157) ni peptide ngufi ya peptide igizwe na acide 15 ya amine, ikomoka ku ruhererekane rwa poroteyine zikingira umubiri mu mutobe wa gastrica. Yerekanye imbaraga nyinshi zo gusana no kurwanya anti-inflammatory mubushakashatsi bwubushakashatsi kandi ifatwa nkumukandida w’ibiyobyabwenge byinshi bya peptide.

Nkibikoresho bya farumasi bikora (API), BPC-157 yakoreshejwe mubice byinshi byubushakashatsi bwa siyansi kwisi yose kugirango isuzume ibikorwa by’ibinyabuzima mu nzira ya gastrointestinal, sisitemu ya musculoskeletal, sisitemu yimitsi, sisitemu yumutima nimiyoboro yoroheje hamwe no gusana ingirabuzimafatizo, cyane cyane mugusana ihahamuka no gukora ubushakashatsi burwanya inflammatory.

Ubushakashatsi hamwe nuburyo bwa farumasi bwibikorwa

BPC-157 yakozweho ubushakashatsi bwimbitse, cyane cyane mubushakashatsi bwibikoko bya vivo no mubyitegererezo bya vitro selile, kandi byagaragaye ko bifite ingaruka zingenzi za farumasi:

1. Kuvugurura imyenda no gusana ihahamuka

Itezimbere imitsi, ligament, amagufwa hamwe nuduce tworoheje twubaka, kandi irashobora kongera angiogenez (angiogenez).

Kwihutisha gukira ibikomere, gusana nyuma yo gukira no gukira ibikomere byoroheje byoroheje, byagenzuwe mubyitegererezo by'inyamaswa nko guturika kw'imitsi, kunanirwa imitsi, no kuvunika.

2. Kurinda igifu no gusana

Mu ngero nka ibisebe byo mu gifu, enterite, na colitis, BPC-157 igira ingaruka zikomeye zo kurinda mucosal.

Irashobora kurwanya kwangirika kwa gastrointestinal iterwa n'imiti idafite imiti igabanya ubukana (NSAIDs) kandi igatera gukira mu mara.

3. Kurwanya inflammatory na immunomodulatory

Igenga uburinganire bwimikorere yubudahangarwa mu guhagarika ibintu bitera umuriro (nka TNF-α, IL-6) no kugenzura ibintu birwanya inflammatory.

Ifite agaciro gashoboka nk'ubuvuzi bufasha indwara zidakira nka ** rheumatoid arthritis n'indwara y'amara (IBD) **.

4. Neuroprotection na neuroregeneration

Muri moderi nyuma yo gukomeretsa umugongo, kwandura imitsi, hamwe nubwonko bwamaraso, BPC-157 irashobora guteza imbere imitsi no kugabanya kwangirika kwimitsi.

Irashobora kurwanya ibibazo biri mubice byubwonko bwo mu mutwe nko guhangayika, kwiheba, no guterwa n'inzoga (icyiciro cyubushakashatsi).

5. Kurinda umutima nimiyoboro y'amaraso

BPC-157 irashobora guteza imbere imiyoboro y'amaraso no guteza imbere gusana mikorobe, kandi ikekwa ko igira ingaruka nziza ku ndwara nka ischemia myocardial ischemia, trombose de vene, no gukomeretsa kwa arterial.

Ibisubizo byubushakashatsi nubushakashatsi

Nubwo BPC-157 itaremerwa cyane kumiti yandikiwe abantu, yerekanye mubushakashatsi bwinyamaswa:

Kwihuta gukomeye kwigihe cyo gusana ingirangingo (nko kwihuta kwa 50% yo gukira imitsi)

Mugabanye ku buryo bugaragara ikibazo cyo kuva amaraso mu gifu, gukomeretsa mu mara, n'ibisebe byo mu mara

Kunoza imitekerereze ya nervice no kongera imikorere yakarere kegeranye

Ongera angiogenezi na granulation tissue igipimo

Bitewe nibi bisubizo, BPC-157 ihinduka molekile yumukandida wubushakashatsi mubijyanye no gusubiza mu buzima busanzwe nyuma y’ihungabana, gukomeretsa siporo, indwara zo mu gifu, n’indwara zifata ubwonko.
Umusaruro wa API no kugenzura ubuziranenge

BPC-157 API itangwa nitsinda ryacu rya Gentolex ryemeza inzira ikomeye ya synthesis (SPPS) kandi ikorwa mubihe bya GMP. Ifite ibintu bikurikira:

Isuku ryinshi: ≥99% (HPLC detection)

Ibisigisigi bike byanduye, nta endotoxine, nta mwanda uremereye

Gufata neza, gusubiramo cyane, gushyigikira urwego rwo gukoresha

Shigikira garama na kilo urwego rwo gutanga kugirango uhuze ibikenewe mubyiciro bitandukanye kuva R&D kugeza inganda.