Carbetocine kugirango wirinde kwandura kwa nyababyeyi no kuva amaraso nyuma yo kubyara
Ibisobanuro birambuye
| Izina | CARBETOCIN |
| Numero ya CAS | 37025-55-1 |
| Inzira ya molekulari | C45H69N11O12S |
| Uburemere bwa molekile | 988.17 |
| Umubare wa EINECS | 253-312-6 |
| Kuzunguruka byihariye | D -69.0 ° (c = 0,25 muri 1M acide acetike) |
| Ingingo yo guteka | 1477.9 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.218 ± 0.06 g / cm3 (Biteganijwe) |
| Imiterere yo kubika | -15 ° C. |
| Ifishi | ifu |
Synonyme
BUTYRYL-TYR (NJYE) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS);BUTYRYL-TYR (NJYE) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT;(BUTYRYL1, TYR (NJYE) 2) -1-CARBAOXYTOC INTRIFLUOROACETATESALT;(BUTYRYL1, TYR (NJYE) 2) -OXYTOCIN;(BUTYRYL1, TYR (NJYE) 2) -OXYTOCINTRIFLUOROACETATESALT;CARBETOCIN;CARBETOCINTRIFLUOROACETATESALT;(2-O-METHYLTYROSINE) -DE-AMINO-1-CARBAOXYTOCIN
Igikorwa cyibinyabuzima
Carbetocin, oxytocine (OT) igereranya, ni oxytocine reseptor agonist hamwe na Ki ya 7.1 nM.Carbetocine ifitanye isano ryinshi (Ki = 1.17 μM) kuri chimeric N-terminus ya reseptor ya oxytocine.Carbetocine ifite ubushobozi bwo gukora ubushakashatsi nyuma yo kuva amaraso.Carbetocine irashobora kwinjira mumaraso yubwonko bwamaraso kandi ikagira ibikorwa bisa na antidepressant mugukoresha reseptor ya oxytocine muri CNS.
Imikorere
Carbetocine ni sintetike ndende ikora oxytocine 8-peptide igereranya na agonist, kandi ivuriro ryayo na farumasi irasa na oxytocine isanzwe ibaho.Kimwe na oxytocine, karbetocine ihuza imisemburo ya hormone yimitsi ya nyababyeyi yoroheje, igatera injyana ya nyababyeyi, ikongera inshuro zayo kandi ikongera ijwi rya nyababyeyi hashingiwe ku kugabanuka kwumwimerere.Urwego rwa Oxytocine rwakira muri nyababyeyi ruri hasi muri leta idatwite, kwiyongera mugihe utwite, no hejuru mugihe cyo gukora.Kubwibyo, karbetocine nta ngaruka igira kuri nyababyeyi idatwite, ariko igira ingaruka zikomeye zo kubyara kuri nyababyeyi itwite ndetse na nyababyeyi nshya.
Hindura Igenzura
Impinduka zigenzurwa ukurikije inzira.Ukurikije ingaruka n'ingaruka n'uburemere, impinduka zashyizwe mubikorwa nka Major, Ntoya na Urubuga.Guhindura urubuga bigira ingaruka nke kumutekano nubuziranenge bwibicuruzwa, bityo ntibikeneye kwemezwa no kubimenyeshwa kubakiriya;Impinduka nto zigira ingaruka ziciriritse kumutekano nubwiza bwibicuruzwa, kandi bigomba kumenyesha abakiriya;Impinduka nini zigira ingaruka zikomeye kumutekano nubwiza bwibicuruzwa, kandi bikeneye kwemezwa nabakiriya.
Ukurikije uburyo, kugenzura kugenzura bitangirana nimpinduka zikoreshwa muburyo bwo guhindura ibisobanuro hamwe no gushyira mu gaciro impinduka zasobanuwe.Isuzuma noneho rikorwa nyuma yo gusaba, bikorwa no kugenzura impinduka zishinzwe.Hagati aho, kugenzura impinduka zashyizwe mubyiciro byingenzi, urwego rusange na urwego ruto.Nyuma yisuzuma rikwiye kimwe no gutondekanya, kugenzura urwego rwose rugomba kwemezwa numuyobozi wa QA.Igenzura rihinduka rikorwa nyuma yo kwemezwa ukurikije gahunda y'ibikorwa.Igenzura rihinduka ryarangije gufungwa nyuma QA yemeje ko igenzura ryashyizwe mubikorwa neza.Niba harimo kumenyesha abakiriya, umukiriya agomba kumenyeshwa mugihe nyuma yo kugenzura impinduka zemejwe
