Bremelanotide

Bremelanotide API

Bremelanotideni ihuriromelanocortin reseptor agonistyatejwe imbere yo kuvurahypoactive irari ry'ibitsina (HSDD) in abagore batwite. Nkubuvuzi bwa mbere bukora hagati yubuvuzi bwemewe na HSDD, Bremelanotide yerekana iterambere rikomeye mubuzima bwimibonano mpuzabitsina.

Byemejwe na FDA yo muri Amerika muri 2019 mwizina ryikirangoVyleesi, Bremelanotide itanga igisubizo gikenewe, kidafite imisemburo kubagore bahura nubushake buke bwimibonano mpuzabitsina, bidashobora gusobanurwa nibibazo byubuvuzi, imitekerereze, cyangwa umubano.

IwacuBremelanotide APIikorwa hifashishijwe icyiciro cya peptide synthesis (SPPS), ikemeza neza ko ifite isuku ryinshi, umwanda muke, hamwe no guhora bikwiranye nubuvuzi nubucuruzi.

Uburyo bwibikorwa

Bremelanotide ikora nagukora reseptor ya melanocortin, cyane cyaneMC4R (reseptor ya melanocortin-4)insisitemu yo hagati. Uku gukora kwizerwa guhindura inzira murihypothalamusbigira uruhare mu gukangura imibonano mpuzabitsina no kwifuza.

Ingaruka z'ingenzi zirimo:

• Byongerewe imbaragaibimenyetso bya dopaminergique, guteza imbere inyungu zishingiye ku gitsina

• Kurwanya inzira zibuza zigira ingaruka kuri libido

• Guhindura sisitemu yo hagatiudashingiye ku misemburo yimibonano mpuzabitsina (non-estrogene, non-testosterone)

Ubu buryo butuma Bremelanotide itandukana nubuvuzi gakondo bwa hormone kandi bukwiranye nabagore benshi.

Ubushakashatsi bwa Clinical & Ibisubizo

Bremelanotide yasuzumwe muri byinshiIcyiciro cya 2 nicyiciro cya 3 ibizamini byamavuriro, irimo ibihumbi by'abagore basuzumwe na HSDD.

Ibisubizo by'ingenzi birimo:

• Iterambere rigaragaramu manota yo kwifuza imibonano mpuzabitsina (yapimwe na FSFI-d)

• Kugabanuka mubibazo bijyanye nubushake buke bwimibonano mpuzabitsina (bipimwa na FSDS-DAO)

• Gutangira ibikorwa byihuse(mu masaha), kubemereragukoreshwa kubisabwa mbere yimibonano mpuzabitsina

• Kugaragaza imikorere myiza mu bagorehamwe kandi nta na comorbid conditions(urugero, kwiheba, guhangayika)

Mu bushakashatsi bw’amavuriro, kugeza25% –35%y'abarwayi bagize iterambere ryiza na placebo.

Umutekano no kwihanganirana

• Ingaruka zikunze kugaragara zirimoisesemi, flushing, nakubabara umutwe- muri rusange byoroheje kandi bigarukira.

• Bitandukanye na melanocortin ya mbere, Bremelanotide nibitajyanye no kwiyongera gukabije k'umuvuduko w'amaraso cyangwa umuvuduko w'umutimamu barwayi benshi.

• Nkubuvuzi bukenewe, birinda imisemburo idakira kandi irashobora gukoreshwa muburyo bworoshye.

Inganda nubuziranenge

IwacuBremelanotide API:

• Ihinduranya ukoresheje SPPS igezweho kandi ikora neza

• Yujuje amahame mpuzamahanga akomeye kuriubuziranenge, indangamuntu, hamwe nibisigara bisigaye

• Birakwiriye gutera inshinge (nk'amakaramu ya autoinjector yuzuye)

• Birashobokaicyiciro cyindege nubucuruzi-buke, gushyigikira byombi R&D no gutanga isoko

Ubushobozi bwo kuvura

Kurenga HSDD, uburyo bwa Bremelanotide bwateye inyungu mubindi bice byaguhuza ibitsina na neuroendocrine modulation, harimo:

• Imikorere mibi yumugabo

• Imyitwarire idahwitse

• Ibyifuzo byo kurya no gukoresha ingufu (binyuze muri sisitemu ya melanocortin)

Umwirondoro wacyo uranga peptide hamwe nibikorwa bya nerviste yo hagati bikomeje gushyigikira iterambere rishoboka mubice bivura.