Linaclotide yo Kurwara Gastrointestinal 851199-59-2
Ibisobanuro birambuye
| Izina | Linaclotide |
| Numero ya CAS | 851199-59-2 |
| Inzira ya molekulari | C59H79N15O21S6 |
| Uburemere bwa molekile | 1526.74 |
Synonyme
Linacllotide; Linaclotide; LinaelotideAcetate; Linaelotide; CY-14; Liclotide; Argpessin; L-Tyrosine, L-sisitemu L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cycle (1 → 6), (2 → 10), (5 → 13) -tris (disulfide)
Ibisobanuro
Linaclotide, imiterere ya peptide ya peptide irimo aside amine 14, ifitanye isano na endogenous guanosine peptide yumuryango kandi niyo miti yonyine yemewe na FDA ya GC-C (guanylate) Cyclase-C) imiti igabanya ubukana bwa syndrome de munda (IBS- C) hamwe na idipopique idakira (CIC) mubantu bakuru.
Ibikoresho bya Shimi
Linaclotide ni ifu yera-yera-ifu ya amorphous;gushonga gato mumazi hamwe na sodium ya chloride yo mumazi (0.9%).
Uburyo ikora
Linaclotide ni guanylate cyclase-C reseptor agonist (GCCA) hamwe nibikorwa bya analgesique na endocrine.Byombi linaclotide hamwe na metabolite ikora irashobora guhuza na guanylate cyclase-C (GC-C) reseptor hejuru yumucyo wa epitelium ntoya.Mubyitegererezo byinyamanswa, linaclotide igabanya ububabare bwimyanya ndangagitsina kandi ikongera inzira ya gastrointestinal binyuze mumikorere ya GC-C, kandi mubantu, ibiyobyabwenge nabyo byongera inzira ya colonike.Igisubizo cyo gukora GC-C cyongerewe imbaraga hamwe na cGMP idasanzwe (cyclic guanosine monophosphate).CGMP idasanzwe irashobora kugabanya ibikorwa byububabare bwimyanya myibarukiro no kugabanya ububabare bwimitsi yinyamaswa ntangarugero.Indwara ya cGMP irashobora kongera ururenda rwa chloride na bicarbonate mu mara mato ukoresheje CFTR (cystic fibrosis transmembrane conductance regulor), amaherezo iganisha ku kwiyongera kw'amazi mato mato n'umuvuduko wo gutembera mu mara mato.
Ibibazo
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