Cagrilintide

Ibisobanuro bigufi:

Cagrilintide ni syntetique, ikora amylin reseptor agonist ikora igihe kirekire kugirango ivure umubyibuho ukabije hamwe nuburwayi bwa metabolike. Mu kwigana imisemburo isanzwe amylin, ifasha kugenzura ubushake bwo kurya, gutinda kwa gastrica, no kongera guhaga. Isuku yacu-Cagrilintide API ikorwa hifashishijwe synthesis ya chimique kandi yujuje ubuziranenge bwa farumasi, bigatuma ikoreshwa muburyo bwo gucunga neza ibiro.

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Ibicuruzwa birambuye

Ibicuruzwa

Cagrilintide API

Cagrilintideni birebire-bikora, muburyo bwa shimiamylin reseptor agonist, yatejwe imbere nk'ubuvuzi bushya kuriumubyibuho ukabije hamwe nuburemere bujyanye no guhindagurika. Yashizweho kugirango yigane ingaruka zaumuntu amylin, imisemburo ifatanije na insuline na pancreatic β-selile, igira uruhare runini mugutunganya ibiryo, gusiba gastric, no guhaga.

Cagrilintide iri gutezwa imbere nka arimwe mu cyumweru kuvura inshinge, gutanga igisubizo cyiza cyane kurigucunga ibiro bidakira, cyane cyane iyo ikoreshwa muriguhuza hamwe na GLP-1 reseptor agonistnkaSemaglutide.

Uburyo bwibikorwa

Cagrilintide ikora ingaruka zayo zo kuvura muguhuza no gukoraamylin, biganisha kuri:

Kuribwa no kurya
Gutinda gusya gastric, byongerera ibyiyumvo byuzuye
Kugabanya intungamubiri za calorie no kongera guhaga

Aya mabwiriza menshi yo gufata ibiryo bituma aba umukandida mwiza wo kuyoboraumubyibuho ukabije hamwe ningaruka ziterwa na cardiometabolic.

Ubushakashatsi namakuru yubuvuzi

Cagrilintide yerekanye ibisubizo bitanga umusaruro mubigeragezo byinshi byamavuriro, harimoIcyiciro cya 2 ubushakashatsi bwakozwe na Novo Nordisk:

Iyo ikoreshwawenyine, Cagrilintide iganisha kurikugabanya ibiro, hamwe na kugezaKugabanya ibiro 10.8%ibyumweru birenga 26 kubantu bafite umubyibuho ukabije.
Igihebyahujwe na Semaglutide, kugabanya ibiro byongerewe cyane-kubigerahokugabanuka cyane muburemere bwumubiri kuruta umukozi wenyine.
Yerekanyekwihanganira ibyizanaumwirondoro urambye wumutekano, hamwe nibintu byinshi bibi ari ibimenyetso byoroheje gastrointestinal.

Ubu buryo bwo guhuza ni igice cyingenzi cyaibisekuru bizaza birwanya ibiyobyabwenge, ugamije inzira nyinshi zo guhaga (amylin + GLP-1).

API Ubwiza nogukora

IwacuCagrilintide API:

Byakozwe binyuze murwego rwo hejurusynthesis ikomeye ya peptide (SPPS)hamwe nubuziranenge buhanitse hamwe nubutunzi bwimiti
Byaremewegutera inshinge
Guhura mpuzamahangaibipimo bya farumasi (ICH, GMP, FDA)
Birashoboka muriicyitegererezo kugeza ku bicuruzwa byapimwe, bikwiranye no gukoresha amavuriro n'inganda

Ubushobozi bwo kuvura

Cagrilintide yerekana auburyo bushyamu gucunga ibiro birenze GLP-1 monotherapy. Umwirondoro wibikorwa byuzuzanya bituma ubera:

Umubyibuho ukabije n'abarwayi bafite ibiro byinshi(hamwe na diyabete cyangwa idafite)
Ubuvuzikugirango wongere ibiro
Iterambere ry'ejo hazaza murisyndrome de metabolic na prediabete