Semaglutide ya Diyabete yo mu bwoko bwa 2

Semaglutide ni igisekuru gishya cya GLP-1 (glucagon-isa na peptide-1) igereranya, kandi semaglutide nuburyo bwa dosiye ndende ikora ishingiye kumiterere shingiro ya liraglutide, igira ingaruka nziza mukuvura diyabete yo mu bwoko bwa 2.Novo Nordisk yarangije icyiciro cya 6 cya IIIa cyo gutera inshinge za semaglutide, anatanga icyifuzo gishya cyo kwandikisha imiti yo gutera inshinge za semaglutide buri cyumweru mubuyobozi bw’ibiribwa n’ibiyobyabwenge muri Amerika (FDA). Ikigo gishinzwe imiti y’uburayi (EMA).

Ugereranije na liraglutide, semaglutide ifite urunigi rurerure kandi rwongera hydrophobicity, ariko semaglutide ihindurwa numurongo mugufi wa PEG, kandi hydrophilique yayo irazamuka cyane.Nyuma yo guhindura PEG, ntishobora guhuza gusa na albumin, gutwikira site ya hydrolysis ya enzymatique ya DPP-4, ariko kandi igabanya gusohora impyiko, ikongerera ubuzima ubuzima bwa kabiri, kandi ikagera ku ngaruka zo kuzenguruka igihe kirekire.