CJC-1295

CJC-1295 API

CJC-1295ni synthique, tetrasubstituted peptide analogue yaimisemburo yo gukura irekura imisemburo (GHRH), Byashizweho Kurigukangura no gukomeza gusohora imisemburo ikura ya endogenous (GH). Bitandukanye na GHRH kavukire, ifite igice gito cyubuzima, CJC-1295 ikubiyemo aIkoranabuhanga rya Affinity Complex (DAC), kubemerera guhambiranya alubumu mumaraso kandikongerera ubuzima bwa kimwe cya kabiri ubuzima bwiminsi irenga 8. Ubu bushya butuma CJC-1295 aigihe kirekire GHRH analoguehamwe n'ubushobozi bukomeye murikurwanya gusaza, kubura imikurire, kugenzura metabolike, guta imitsi, n'ubuvuzi bushya.

Uburyo bwibikorwa

CJC-1295 ikora kuriGHRHgiherereye kuri selile ya somatotropique muri glande yimbere. Imikorere yibinyabuzima yigana iya GHRH kavukire, ariko hamwe nigice kinini cyubuzima bwagutse cyane kubera guhindura DAC. Iki gikorwa kirambye kirashobozairekurwa rya pulsatile ihamye ya GHno kongera umusaruro wainsuline imeze nkikura 1 (IGF-1).

Uburyo bw'ingenzi burimo:

• Gukangura ururenda rwa endogenous GH

• Kuzamuka igihe kirekire kurwego rwa IGF-1, gushyigikira ingaruka za anabolike

• Nta gutandukana gukomeyecyangwa kugabanuka hamwe no gukomeza gukoresha

• Lipolysis yongerewe imbaraga, synthesis ya protein, hamwe no kuvugurura selile

Mugukurura inzira ya GH na IGF-1 inzira, CJC-1295 irinda byinshi mubitagenda neza bifitanye isano nubuvuzi bwa GH budasanzwe, nko kwanga reseptor no guhangayikishwa numutekano.

Ubushakashatsi bwo kuvura hamwe nubushobozi bwa Clinical

1. Gukura kwa Hormone (GHD)

Mu bigeragezo byambere byamavuriro, CJC-1295 yerekanye:

• Kwiyongera kurambye muriGHnaIGF-1urwego kugeza kuriIminsi 6-10nyuma yo guterwa inshinge imwe

• Kugabanukainshuro inshingeugereranije na GHRH ya buri munsi cyangwa inshinge za GH

• Kunoza kubahiriza abarwayi no gutuza kwa hormone

2. Ibigize umubiri no kubungabunga imitsi

Ubushakashatsi bw’inyamaswa n’abantu bwerekanye ko CJC-1295:

• Guteza imberekwiyongera kw'imitsinaigabanya ibinure byumubiri, cyane cyane ibinure

• Gutezimberekugumana azote hamwe na synthesis ya proteinmumitsi ya skeletale

• Turashobora gufasha mukugarura kuvasarcopenian'imiterere yo guta imitsi

3. Kurwanya gusaza hamwe nubuzima bwiza

Nkuko urwego rwa GH na IGF-1 rusanzwe rugabanuka uko imyaka igenda ishira, CJC-1295 iragenda yiga nka ankurwanya kurwanya gusazaKuri:

• Gutezimberegusinzira nezanainjyana ya circadian

• Kuzamurauruhu rworoshye, ubwinshi bwamagufwa, naimikorere yubudahangarwa

• Inkungaimbaraga metabolismnakurwanya umunaniro

4. Amabwiriza ya Metabolic

CJC-1295 yerekana amasezerano mugukemuraKurwanya insulinesyndrome de metabolike na:

• Gutezimberegukoresha glucose

• Gutezimbereokiside ya lipidenaadipose tissue metabolism

• Gushyigikiragucunga ibirokubantu bafite umubyibuho ukabije cyangwa mbere ya diyabete

API Gukora no kugenzura ubuziranenge

At Itsinda rya Gentolex, iwacuCJC-1295 APIni Byakozwesynthesis ikomeye ya peptide (SPPS)no kwezwa ukoresheje HPLC kugirango ugere ku isuku ryinshi no mu cyiciro kimwe.

Ibisobanuro by'ingenzi:

• Isuku ≥ 99%(HPLC yemeje)

• Umuyoboro muke usigaye hamwe nicyuma kiremereye

• Endotoxine-yubusa, inzira ya synthesis idafite immunogenic

• Birashobokaingano yihariye: miligarama kugeza ku kilo

Porogaramu hamwe nigihe kizaza

CJC-1295 ifatwa nkimwe mubyiringiro birebire-bigereranywa na GHRH, hamwe nibisabwa muri:

• Ubuvuzi bukuze bwa GH

• Imicungire yumubiri mubyibushye no gusaza

• Gusubiza mu buzima busanzwe imitsi cyangwa ihahamuka

• Kongera imikorere no gukira muburyo bwa clinique cyangwa siporo

• Ubuvuzi bufasha mumunaniro udashira, fibromyalgia, hamwe nuburinganire bwa neuroendocrine

Ibigeragezo bikomeje kwivuza birimo gushakisha imikoreshereze yabyorecombinant GH, cyane cyane mubantu bashakaumutekano, imisemburo myinshi ya physiologique.