Leuprorelin Acetate igenga ibanga rya Gonadal Hormone
Ibisobanuro birambuye
| Izina | Leuprorelin |
| Numero ya CAS | 53714-56-0 |
| Inzira ya molekulari | C59H84N16O12 |
| Uburemere bwa molekile | 1209.4 |
| Umubare wa EINECS | 633-395-9 |
| Kuzunguruka byihariye | D25 -31.7 ° (c = 1 muri 1% acide acetike) |
| Ubucucike | 1.44 ± 0.1 g / cm3 (Biteganijwe) |
| Imiterere yo kubika | -15 ° C. |
| Ifishi | Isuku |
| Coefficient ya acide | (pKa) 9.82 ± 0.15 (Biteganijwe) |
| Amazi meza | Gushonga mumazi kuri 1mg / ml |
Synonyme
LH-RHLEUPROLIDE; LEUPROLIDE; LEUPROLIDE (UMUNTU); LEUPRORELIN; [DES-GLY10, D-LEU6, PRO-NHET9] DES-GLY10, D-LEU6, PRO-NHET9) -LUTEINIZINGHORMONE-RELASINGFACTOR; [DES-GLY10, D-LEU6, PRO-NHET9] -LH-RH (UMUNTU)
Ingaruka ya Farumasi
Leuprolide, goserelin, triprelin, na nafarelin ni imiti myinshi ikoreshwa mubikorwa byubuvuzi kugirango ikuremo intanga ngabo zo kuvura kanseri y'ibere mbere yo gucura na kanseri ya prostate..Nukuvuga ko gonadotropine isohorwa na pitoito igabanuka, bigatuma igabanuka rikabije ryimisemburo yimibonano mpuzabitsina isohoka nintanga ngore.
Leuprolide ni imisemburo ya gonadotropine irekura (GnRH), peptide igizwe na acide 9 amine.Iki gicuruzwa kirashobora guhagarika neza imikorere ya sisitemu ya pitoitar-gonadal, kurwanya imisemburo ya proteolyique no guhuza reseptor ya GnRH ikomera kuruta GnRH, kandi igikorwa cyo guteza imbere irekurwa rya hormone ya luteinizing (LH) nikubye inshuro 20 ko ya GnRH.Ifite kandi imbaraga zikomeye zo kubuza imikorere ya pituito-gonad kuruta GnRH.Mu cyiciro cya mbere cyo kuvura, imisemburo itera imisemburo (FSH), LH, estrogene cyangwa androgene irashobora kwiyongera by'agateganyo, hanyuma, kubera kugabanuka kwa glande ya pitoito, gusohora kwa FSH, LH na estrogene cyangwa androgene, bikavamo kwishingikiriza kumisemburo yimibonano mpuzabitsina.Indwara zishingiye ku gitsina (nka kanseri ya prostate, endometriose, nibindi) zigira ingaruka zo kuvura.
Kugeza ubu, umunyu wa acetate wa leuprolide ukoreshwa cyane cyane mubuvuzi, kubera ko imikorere ya acupate ya leuprolide ihagaze neza mubushyuhe bwicyumba.Amazi agomba gutabwa.Irashobora gukoreshwa mukuvura imiti ivura endometriose na fibroide ya nyababyeyi, ubwangavu bwibanze, kanseri y'ibere mbere yo gucura na kanseri ya prostate, ndetse no kuva amaraso munda ibyara yanduye cyangwa adafite akamaro ko kuvura imisemburo isanzwe.Irashobora kandi gukoreshwa nkubushake mbere yo kwangirika kwa endometrale, ishobora kunaniza endometrium, kugabanya uburibwe, no kugabanya ingorane zo kubaga.
