Fmoc-L-Lys [Eic (OtBu) -γ-Glu (OtBu) -AEEA] -OH

Fmoc-L-Lys [Eic (OtBu) -γ-Glu (OtBu) -AEEA] -OH

Gusaba Ubushakashatsi:
Uru ruganda nirinda lysine rukoreshwa, rukoreshwa muri synthesis ya peptide no guteza imbere ibiyobyabwenge. Irimo itsinda rya Fmoc kurinda N-terminal, hamwe no guhindura urunigi kuruhande hamwe na Eic (OtBu) (inkomoko ya acide eicosanoic), acid-glutamic aside (γ-Glu), na AEEA (aminoethoxyethoxyacetate). Ibi bice byateguwe kugirango bige ku ngaruka za lipidation, chimie spacer, no kugenzura ibiyobyabwenge. Irakorwaho ubushakashatsi cyane murwego rwingamba za prodrug, guhuza ADC, na peptide ikorana na membrane.

Imikorere:
Fmoc-L-Lys [Eic (OtBu) -γ-Glu (OtBu) -AEEA] -OH ikora nk'inyubako yo guhuza peptide yahinduwe na peptide cyangwa uburyo bwo gutanga ibiyobyabwenge. Imyitwarire ya Eic itezimbere lipofilicity hamwe na membrane ihuza; γ-Glu yongeramo ituze ryimikorere kandi igamije ubushobozi; na AEEA ikora nka hydrophilique ihuza byoroshye. Hamwe na hamwe, bashoboza kubaka peptide hamwe no kongera ingirabuzimafatizo, kwagura igice cyubuzima, hamwe nibintu byihariye byo gutanga.