Daptomycine 103060-53-3 Indwara Zandura
Ibisobanuro birambuye
| Izina | Daptomycin |
| Numero ya CAS | 103060-53-3 |
| Inzira ya molekulari | C72H101N17O26 |
| Uburemere bwa molekile | 1620.67 |
| Umubare wa EINECS | 600-389-2 |
| Ingingo yo gushonga | 202-204 ° C. |
| Ingingo yo guteka | 2078.2 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.45 ± 0.1 g / cm3 (Biteganijwe) |
| Ingingo ya Flash | 87 ℃ |
| Imiterere yo kubika | Ikidodo cyumye, Ubike muri firigo, munsi ya -20 ° C. |
| Gukemura | Methanol: soluble5mg / mL |
| Coefficient ya acide | (pKa) 4.00 ± 0.10 (Biteganijwe) |
| Ifishi | ifu |
| Ibara | ibara ritagira ibara ry'umuhondo |
Synonyme
N- [N- (1-Oxodecyl) -L-Trp-D-Asn-L-Asp -] - cyclo [L-Thr * Gly-D-Ser - [(3R) -3-methyl-L-Glu -] - 4- (2-aminophenyl) -4-oxo-L-Abu -]; N- D-Asn-L-Asp -] - cyclo [Thr * -Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser - [(3R) -3-methyl-L- Glu -] - 3- (2-aminobenzoyl) -L-Ala -]; N- (1-Oxodecyl) -L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl- (3R) -3-methyl-L-α-glutamyl-α, 2-diamino-γ-oxo-benzenebutanoicacid (13-4) lactone; DAPTOMYCINE; Dapcin; Daptomycin,> = 99%; DaptomycinReadyMadeSolution; Daptomycin (LY146032)
Ibisobanuro
Antibiyotike ya daptomycine ni antibiyotike ya lipopeptide ya cyclicique ifite imiterere mishya yakuwe mu musemburo wa fermentation ya Streptomyces (S. reseosporus), ikabuza biosynthesis ya bagiteri ya peptidoglycan guhungabanya ubwikorezi bwa aside amine muri selile.Guhindura imiterere ya cytoplasmeque membrane irashobora guhagarika imikorere ya bagiteri mumikorere myinshi kandi ikica byihuse bacteri nziza.Usibye ubushobozi bwayo bwo gukora kuri bacteri zifitanye isano na Gram-positif, daptomycine ni ingenzi cyane kumiterere yihariye yerekanaga methicilline, vancomycine, na linezolide muri vitro.Ifite ibikorwa bikomeye, kandi uyu mutungo ufite akamaro gakomeye kumavuriro kubarwayi banduye cyane.Umusonga wa Eosinophilique ni indwara idasanzwe kandi ikomeye cyane ifite ibimenyetso birimo umuriro, inkorora, guhumeka neza, no guhumeka neza.
Ingaruka ya Antibacterial
Daptomycine ifite ibikorwa byiza bya bacteriostatike irwanya antibiyotike zitandukanye zirwanya antibiyotike, nka MIC = 0.06-0.5 μg / ml kuri methicillin irwanya Staphylococcus aureus (MRSA), hamwe na methicilline irwanya Staphylococcus aureus (MRSA).MIC = 0,02525 ya Enterococcus ni 0.5 ～ 1μg / ml, naho MIC ya Enterococcus irwanya antibiyotike ya glycopeptide ni 1 ～ 2μg / ml.
