Fmoc-L-Lys [Ste (OtBu) -γ-Glu- (OtBu) -AEEA-AEEA] -OH

Fmoc-L-Lys [Ste (OtBu) -γ-Glu (OtBu) -AEEA-AEEA] -OH

Gusaba Ubushakashatsi:
Uru ruganda ni lysine yahinduwe ikoreshwa muri synthesis ya peptide, cyane cyane mukubaka peptide ya conjugate cyangwa intego nyinshi. Itsinda rya Fmoc ryemerera guhuza intambwe ikoresheje Fmoc ikomeye-icyiciro cya peptide synthesis (SPPS). Urunigi rwo ku mpande rwahinduwe hamwe na aside ikomoka kuri stearic (Ste), acid-glutamic aside (γ-Glu), hamwe na AEEA (aminoethoxyethoxyacetate) ebyiri, zitanga hydrophobicity, ibintu byishyuza, hamwe n’imyanya yoroheje. Ubusanzwe yizwe kubera uruhare rwayo muri sisitemu yo gutanga ibiyobyabwenge, harimo antibody-ibiyobyabwenge conjugate (ADCs) na peptide yinjira mu ngirabuzimafatizo.

Imikorere:
Fmoc-L-Lys. Acide stearic yongerera imbaraga membrane, γ-Glu itezimbere ituze hamwe no kurwanya enzymatique, kandi abahuza AEEA batanga ibisubizo kandi bigahinduka. Hamwe na hamwe, iyi mikorere ituma ibice bigira agaciro mugushushanya peptide kugirango binogezwe neza, irekurwa, hamwe nibisabwa kugemura.