Fmoc-Thr (tBu) -Phe-OH

Fmoc-Thr (tBu) -Phe-OH

Gusaba Ubushakashatsi:
Fmoc-Thr (tBu) -Phe-OH ni inyubako ya dipeptide ikunze gukoreshwa muburyo bukomeye bwa peptide ya peptide (SPPS). Itsinda rya Fmoc (9-fluorenylmethyloxycarbonyl) ririnda N-terminus, mugihe itsinda rya tBu (tert-butyl) ririnda hydroxyl kumurongo wa threonine. Iyi dipeptide ikingiwe yizwe kubera uruhare rwayo mu korohereza peptide neza, kugabanya ivanguramoko, no kwerekana imiterere yihariye ikurikirana mu miterere ya poroteyine no mu bushakashatsi bwakozwe.

Imikorere:
Fmoc-Thr. Urunigi rwa threonine rutanga polarite hamwe na fosifora ishobora kuba, mugihe fenylalanine yongeraho imiterere yimpumuro nziza hamwe nuburyo butajegajega. Uku guhuza ni ingirakamaro mugushushanya peptide kubushakashatsi bwibinyabuzima, ubushakashatsi buhuza reseptor, hamwe nibisabwa kuvumbura ibiyobyabwenge.