IBuTamoren Mesylate yongerera ibiro byumubiri, Serum Igf-1 na GH

Ibisobanuro

Ibramolen Mesylate ni ibiyobyabwenge bikora nkimitekerereze ikomeye, yo mu kanwa, yiyongera cyane, yigana ibikorwa bya gh kugirango ashishikarize imisemburo ya ecogetous.

Imikorere

Ibramolen Mesylate yerekanwe kugirango yongere kurekurwa no gutanga umusaruro wa plasma wiyongereyeho imisemburo imwe harimo na gh na insuline ibintu bizima 1 (igf-1 ntabwo bigira ingaruka kurwego rwa Cortisol. Irashobora kuvurwa muri iki gihe ugabanye urwego rwiyi misemburo, nko mu bana cyangwa abageze mu zabukuru bafite imirya y'amagufwa, kandi ubushakashatsi bwa muntu bwerekanye ubucukuzi bw'amagufwa, kandi ubushakashatsi bwa muntu bwiyongereyeho imitsi n'amagufwa adutera abantu bakuru bakuze. Ihindura kandi metabolism yibinure byumubiri, niyo ishobora kuba ifite ibyifuzo byo kuvura umubyibuho ukabije.

Mu bushakashatsi bwa Vivo

Ibuton Mesylate (5 mg / kg / kumunsi) bivamo imibare ikomeye yongera uburemere bwumubiri no kongera serum igf-1 na gh urwego rwimbwa. IBuTamoren Mesylate areka ntayongereyeho muri CSF IGF-1 cyangwa GH kurwego rwa 7 cyangwa 15 mubushakashatsi. Imbeba zitegura hamwe na GH guhagarika ibikorwa bya neurons by ibutamoren Mesylate (50 μg, ip). Mu mbeba ya Knockout, GH na Octreotide bananiwe kubuza IBuTamoren Mesylate Gukora Gukora Neurons. Ubuyobozi budakira bwa MK-0677 bufitanye isano no kwiyongera cyane muri GH na IGF-I Urwego rukomeje igihe cyo kuvura. Umwirondoro wa GH ukurikira Mk-0677 Ubuyobozi bugizwe no kugenzura hejuru. Mk-0677 yongera cyane impeshyi ya GH GH nyuma yubuyobozi bwo mu kanwa. Mk-0677 ni ibanga rinini rya Gh rifatanije byihuse, nini, ndende, ndende irambye mu rwego rwa GH mugihe yatanzwe kumunwa cyangwa iv