Chondroitin Sulfate yo kuvura indwara z'umutima zifata umutima, Arthrite no gukiza ibikomere bya Corneal 98%
Ibicuruzwa birambuye
| Izina | Chondroitin sulfate |
| Numero ya CAS | 9007-28-7 |
| Inzira ya molekulari | C13H21NO15S |
| Uburemere bwa molekile | 463.36854 |
| Umubare wa EINECS | 232-696-9 |
| Amazi meza | Kubora mumazi |
| Isuku | 98% |
| Ububiko | Bika ku bushyuhe busanzwe |
| Ifishi | Ifu |
| Ibara | Cyera kugeza cyera |
| Gupakira | Umufuka wa PE + Aluminium |
Synonyme
poly-1 (2/3) -n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4- (6) sulfonyl-d-galactose;chondroitinpoly sulfate;sulfate ya chondroitin;chondroiti nsulfuricacid;acide ya chondroitine;chonsurid;CSO; (5ξ) -2- (Carboxyamu
Ingaruka ya Farumasi
Ibisobanuro
Chondroitinsulfate (CS) ni acide mucopolysaccharide ikuramo kandi igasukurwa mubice byinyamanswa.Sulfate ya Chondroitin ifite imiterere itandukanye nka A, C, D, E, H na K. Chondroitin sulfate muri kamere iboneka cyane muri karitsiye y’inyamaswa, amagufwa yo mu muhogo, amagufwa yizuru (41% mu ngurube), bovine, septum na trachea (irimo 36% kugeza 39%), izindi nyama nkamagufa yamaguru, ligaments, uruhu, cornea, nibindi nabyo birimo.Ibiri muri karitsiye y amafi birakungahaye cyane, nka 50% kugeza 60% mumagufwa ya shark, na bike cyane mubice bihuza.
Indwara ya coronary atherosclerotic, kwiyongera kwa lipide yamaraso na cholesterol, arteriosclerose, angina pectoris, ischemia myocardial, infocarite myocardial, nibindi mubarwayi barwaye umutima.
Igikorwa cya farumasi
Rapamycin (RAPA) ifite ingaruka zisa na FK506.Mubigeragezo byinshi byamavuriro, ingaruka zabyo wasangaga ziterwa na dose kandi zishobora guhinduka, kandi RAPA kumiti yo kuvura ntabwo yasanze ifite nephrotoxicity ikomeye kandi nta hyperplasia ya gingival.Ingaruka nyamukuru z'uburozi n'ingaruka zirimo: kubabara umutwe, isesemi, kuzunguruka, kuva amaraso, no kubabara hamwe.Muri laboratoire idasanzwe harimo: trombocytopenia, leukopenia, hemoglobine nkeya, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, imisemburo ikabije y'umwijima (SGOT, SGPT), dehydrogenase ya lactate, hypokalemia, Hypomagnesemia, n'ibindi. urwego rwa plasma fosifate rwitwa ko rurerure rwo gusohora fosifate mu mpyiko zatewe na RAPA ishingiye ku buvuzi bwa immunosuppressive.Kimwe nizindi immunosuppressants, RAPA ifite amahirwe menshi yo kwandura, aho bivugwa ko ikunda kongera umusonga cyane, ariko kuba izindi ndwara zanduza amahirwe ntaho zitandukaniye cyane na CsA.
Ingaruka z'uburozi
Chondroitin sulfate ibaho cyane mubice byinyamanswa byabantu ninyamaswa.Gutegura imiti ahanini birimo isomeri ebyiri za chondroitine sulfate A na chondroitin sulfate C, kandi ibikubiye muri sulfate ya chondroitine muri karitsiye yinyamaswa zubwoko butandukanye kandi imyaka iratandukanye.Ingaruka za farumasi nizo zikurikira: sulfate ya chondroitine irashobora gukuraho lipide na lipoproteine mu maraso, kuvana cholesterol mu mitsi y'amaraso ikikije umutima, kwirinda no kuvura aterosklerose, no kongera umuvuduko wa lipide na aside irike mu ngirabuzimafatizo.Chondroitin sulfate irashobora gukumira no kuvura indwara z'umutima.Ifite anti-atherosclerose hamwe na anti-atherogeneque yibibaho byerekana imiterere ya arteriosclerose yubushakashatsi;byongera amashami ya koronari cyangwa kuzenguruka ingwate ya aterosklerose, kandi irashobora kwihutisha coronary arteriosclerose cyangwa embolism.Gukiza, kuvugurura no gusana myocardial necrosis cyangwa degeneration.Irashobora kongera biosynthesis ya selile messenger ribonucleic aside (mRNA) na acide deoxyribonucleic (ADN) kandi ikagira ingaruka zo guteza imbere metabolism.Igikorwa gito cyo kurwanya anticoagulant.Chondroitin sulfate igira ingaruka zingana na anticoagulant, kandi buri mg 1 ya sulfate ya chondroitine A ihwanye nigikorwa cya anticoagulant ya 0.45U ya heparin.Iki gikorwa cyo kurwanya anticoagulant ntabwo gishingiye kuri antithrombine III kugirango igire uruhare rwayo, irashobora gukora anticoagulant ikoresheje sisitemu ya fibrinogen.Chondroitin sulfate ifite kandi anti-inflammatory, gukira ibikomere byihuse n'ingaruka zo kurwanya ibibyimba.
