MOTS-C

Ibisobanuro bigufi:

MOTS-C API ikorwa muburyo bukomeye bwa GMP ikoresheje tekinoroji ya peptide synthesis (SPPS) kugirango ireme neza, isukuye ryinshi kandi ihamye cyane mubushakashatsi no gukoresha imiti.
Ibiranga ibicuruzwa:

Isuku ≥ 99% (byemejwe na HPLC na LC-MS),
Endotoxine nkeya nibisigara bisigaye,
Yakozwe ukurikije ICH Q7 na GMP isa na protocole,
Irashobora kugera ku musaruro munini, uhereye kuri miligarama yo mu rwego rwa R&D kugeza kuri garama-urwego na kilo yo mu rwego rwo gutanga ibicuruzwa.

Ohereza imeri kuri twe

Ibicuruzwa birambuye

Ibicuruzwa

MOTS-C API

MOTS-C(Mitochondrial Gufungura Gusoma Ikadiri ya 12S rRNA Ubwoko-c) ni aside 16-aminomitochondriya ikomoka kuri peptide (MDP)kodegisi na genome ya mitochondrial. Bitandukanye na peptide gakondo ya kirimbuzi, MOTS-c ikomoka mu karere ka 12S rRNA ya ADN ya mitochondial kandi igira uruhare runini murikugenga metabolisme selile, gusubiza ibibazo, hamwe na insuline.

Nka peptide yubuvuzi peptide,MOTS-c APIyungutse inyungu zingenzi mubice byaindwara ya metabolike, gusaza, gukora physiologiya, nubuvuzi bwa mitochondial. Peptide kuri ubu iri gukorwa iperereza ryimbitse kandi ifatwa nkumukandida utanga ikizereibisekuru bizaza peptide ivurakwibasira ubuzima bwa metabolike no kuramba.

Uburyo bwibikorwa

MOTS-c ikora ingaruka zayo binyuzemitochondrial-nucleaire-ibiganiro—Uburyo mitochondriya ivugana na nucleus kugirango ibungabunge homeostasis. Peptide ihindurwa kuva mitochondriya ikajya muri nucleus kugirango isubize ibibazo bya metabolike, aho ikora nka ametabolikemuguhindura imvugo ya gene.

Uburyo bwibanze bwibinyabuzima burimo:

Gukora AMPK (AMP-ikora protein kinase):MOTS-c itera AMPK, sensor yo hagati yingufu, kuzamuragufata glucose, okiside ya aside irike, na biogenezi ya mitochondrial.
Kongera imbaraga za insuline:MOTS-c yongerera insuline kwitabira imitsi na tipusi ya adipose, gutera imbereglucose homeostasis.
Kurwanya impagarara za okiside no gutwika:Muguhindura selile redox iringaniza hamwe ninzira yerekana inzira.
Kugena imikorere ya mitochondial na biogenezi:Shyigikira ubuzima bwa mitochondial, cyane cyane mubihe bigoye cyangwa gusaza.

Ubushakashatsi bwo kuvura ningaruka zibinyabuzima

Ubushakashatsi bwibanze bwerekanye ingaruka zitandukanye za physiologique nubuvuzi bwa MOTS-c haba muri vitro ninyamaswa:

1. Indwara ya Metabolike (Umubyibuho ukabije, Diyabete yo mu bwoko bwa 2, Kurwanya insuline)

Kunoza kwihanganira glucose no kugabanya urugero rwa glucose
Gutezimbereinsulineutarinze kongera urwego rwa insuline
Guteza imberekugabanya ibiro hamwe na okisidemu mirire iterwa n'imbeba zifite umubyibuho ukabije

2. Kurwanya gusaza no kuramba

Urwego rwa MOTS-c rugabanuka uko imyaka igenda ishira, kandi inyongera mu mbeba zashaje zerekanwekongera ubushobozi bwumubiri, kuzamura imikorere ya mitochondial, nagutinda kugabanuka bijyanye n'imyaka.
Kunoza imikorere y'imyitozo kandikwihanganira imitsibinyuze mu kongera imbaraga za okiside metabolism.

3. Kurinda Mitochondrial na Cellular Kurinda Stress

Gutezimberekubaho kwa selile munsi ya metabolike cyangwa okisideimiterere.
Yongera imvugo ya gen ifitanye isanogusana selile na autophagy.

4. Imitsi Yumutima na Neuroprotective Potential

Ubushakashatsi bwibanze bwerekana ko MOTS-c ishobora kurindaselile endothelial selileno kugabanya ibimenyetso byumutima.
Ibishobora kuba neuroprotective properties binyuzeinzira yo kurwanya inflammatory na antioxidative inzirabarimo gukorwaho iperereza.

API Gukora nibiranga ubuziranenge

At Itsinda rya Gentolex, iwacuMOTS-c APIyakozwe hakoreshejwesynthesis ikomeye ya peptide (SPPS)mubihe bikomeye bisa na GMP, byemeza ubuziranenge, ubuziranenge, no gutuza kubushakashatsi no gukoresha imiti.