Liraglutide Kurwanya Diyabete yo Kugenzura Isukari Yamaraso CAS NO.204656-20-2
Ibisobanuro birambuye
| URUBANZA | 204656-20-2 | Inzira ya molekulari | C172H265N43O51 |
| Uburemere bwa molekile | 3751.20 | Kugaragara | Cyera |
| Imiterere yo kubika | Kurwanya urumuri, dogere 2-8 | Amapaki | Umufuka wa aluminium / vial |
| Isuku | ≥98% | Ubwikorezi | Urunigi rukonje hamwe no kubika neza |
Ibigize Liraglutide
Ibikoresho bifatika:
Liraglutide (igereranya glucagon ya muntu isa na peptide-1 (GLP-1) ikorwa n'umusemburo hakoreshejwe ikoranabuhanga rya genoside).
Izina ryimiti:
Arg34Lys26- (N-ε- (γ-Glu (N-α-hexadecanoyl))) - GLP-1 [7-37]
Ibindi bikoresho:
Disodium Hydrogen Fosifate Dihydrate, Propylene Glycol, Acide Hydrochloric na / cyangwa Sodium Hydroxide (nka pH Adjusters Gusa), Fenol, namazi yo gutera inshinge.
Gusaba
Ubwoko bwa diyabete
Liraglutide itezimbere glucose yamaraso.Igabanya hyperglycemia ifitanye isano nifunguro (mumasaha 24 nyuma yubuyobozi) yongera insuline (gusa) mugihe bisabwa mukongera glucose, gutinda gusohora gastrica, no guhagarika ururenda rwa glucagon.
Birakwiriye kubarwayi bafite isukari yamaraso ikomeje kugenzurwa nabi nyuma yimiti myinshi ya metformin cyangwa sulfonylure yonyine.Ikoreshwa ifatanije na metformin cyangwa sulfonylureas.
Ikora muburyo buterwa na glucose, bivuze ko izatera insuline gusohora gusa mugihe glucose yamaraso irenze iyisanzwe, ikarinda "kurenza urugero".Kubwibyo, irerekana ingaruka zitari nke za hypoglycemia.
Ifite ubushobozi bwo guhagarika apoptose no gutera imbaraga za selile beta (bigaragara mubushakashatsi bwinyamaswa).
Igabanya ubushake bwo kurya no kubuza kwiyongera k'umubiri, nkuko bigaragara mubushakashatsi bwakozwe kumutwe na glimepiride.
Igikorwa cya farumasi
Liraglutide nikigereranyo cya GLP-1 hamwe na 97% bikurikirana homologiya kubantu GLP-1, ishobora guhuza no gukora reseptor ya GLP-1.Umuyoboro wa GLP-1 niwo wibasiwe na GLP-1 kavukire, imisemburo ya endogenous incretin itera imisemburo ya glucose iterwa na insuline ituruka mu ngirabuzimafatizo.Bitandukanye na GLP-1 kavukire, imiti ya pharmacokinetic na pharmacodynamic ya liraglutide mubantu ikwiranye no gufata inshuro imwe kumunsi.Nyuma yo gutera inshinge, uburyo bwibikorwa byigihe kirekire birimo: kwishyira hamwe bidindiza kwinjiza;guhuza albumin;Enzyme yo hejuru ihamye bityo plasma ndende yubuzima.
Igikorwa cya liraglutide cyahujwe nubusabane bwihariye na reseptor ya GLP-1, bigatuma kwiyongera kwa cyclic adenosine monophosphate (cAMP).Liraglutide itera ururenda rwa insuline muburyo bushingiye kuri glucose, mugihe igabanya glucose irenze muburyo bwa glucose.
Kubwibyo, iyo glucose yamaraso izamutse, insuline isohoka, mugihe glucagon isohoka.Ibinyuranye, liraglutide igabanya imisemburo ya insuline mugihe cya hypoglycemia itagize ingaruka kuri glucagon.Uburyo bwa hypoglycemic ya liraglutide burimo no kwongerera gato umwanya wo gusiba gastric.Liraglutide igabanya uburemere bwumubiri hamwe namavuta yumubiri kugabanya inzara ningufu.
