Orlistat 96829-58-2 Kugabanya ibyo yinjiza ibinure bya simati, bikaviramo kugabanya ibiro
Ibisobanuro birambuye
| Izina | Orlistat |
| Umubare wa Cas | 96829-58-2 |
| Formulala | C29H53NO5 |
| Uburemere bwa molekile | 495.73 |
| Umubare wa EINECS | 639-755-1 |
| Gushonga | <50 ° C. |
| Ubucucike | 0.976 ± 0.06G / CM3 (Byahanuwe) |
| Imiterere | 2-8 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Coeffity | (PKA) 14.59 ± 0.23 (byahanuwe) |
Synonyme
. Ormyl-l-leucine (1s) -1 - [((((2s)-1-oxtanyl]
Ingaruka ya farumasi
Umutungo
Ifu yera Molekile yayo ni diastereomer irimo ibigo bine bya chiral, ku burebure bwa 529nm, igisubizo cyacyo cya ethanol gifite impeta mbi.
Uburyo bw'ibikorwa
Orlistat ni igihe kirekire kandi gikomeye cya lipase yihariye, ihuza imisemburo ebyiri zavuzwe haruguru zikora ubumwe bwa coszy hamwe na seriveri ikora cyane ya lipase mu gifu no mu mara nto. Enzymes idakora ntishobora kumena ibinure mubiryo mumavuta yubusa na chimical glycerol ishobora kwinjizwa numubiri, bityo bigabanya gufata ibinure no kugabanya ibiro. Byongeye kandi, ubushakashatsi bumwe na bumwe bwasanze orlistat ibuza kwinjiza mu mara mu maraso ubuza niemann-gutoranya c1 nka poroteyine 1 (Niemann-Pickc1 - NPC1L1).
Ibimenyetso
Iki gicuruzwa gihuza nimirire yoroheje kigaragazwa no kuvura igihe kirekire kubantu bafite umubyibuho ukabije kandi ufite ibiro byinshi, harimo nabafite ibyago byashyizweho bifitanye isano numubyibuho ukabije. Iki gicuruzwa gifite uburemere bwigihe kirekire (Gutakaza ibiro, kubungabunga ibiro no kwirinda gusubiramo). Gufata orlistat birashobora kugabanya ibintu bifitanye isano n'ibyifuzo no guhangayikishwa n'izindi ndwara ziterwa n'umubyibuho ukabije, harimo na hypercholesterolemia, harimo hypercholesterolemia, harimo na diyabete y'ubwoko bwa 2, ubunganirane.
Imikoranire yubuvuzi
Irashobora kugabanya kwinjiza vitamine A, D na E. Irashobora kongerwaho hamwe nibicuruzwa icyarimwe. Niba urimo kwitegura urimo vitamine A, D na E (nka benshi), ugomba gufata iki gicuruzwa amasaha 2 nyuma yo gufata iki gicuruzwa cyangwa igihe cyo kuryama. Abantu bafite diyabete yo mu bwoko bwa 2 barashobora gukenera kugabanya ibipimo bya my of defaliclycemict (urugero, sulfoorelureas). Ubuyobozi hamwe na Cyclopsone bushobora kuvamo kugabanuka kwa plasma kwibanda kuri nyuma. Gukoresha Amuodarone birashobora kuvamo kugabanuka kwa nyuma no kugabanya ingaruka.
