Orlistat 96829-58-2 Kugabanya Absorption yibinure bya Sietary, bivamo gutakaza ibiro
Ibicuruzwa birambuye
| Izina | Orlistat |
| Numero ya CAS | 96829-58-2 |
| Inzira ya molekulari | C29H53NO5 |
| Uburemere bwa molekile | 495.73 |
| Umubare wa EINECS | 639-755-1 |
| Ingingo yo gushonga | <50 ° C. |
| Ubucucike | 0.976 ± 0.06g / cm3 (Biteganijwe) |
| Imiterere y'ububiko | 2-8 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Coefficient ya acide | (pKa) 14.59 ± 0.23 (Byahanuwe) |
Synonyme
(S) -2-FORMYLAMINO-4-METHYL-PENTANOICACID (S) -1 - [ ORMYL-L-LEUCINE (1S) -1 - [
Ingaruka ya Farumasi
Ibyiza
Ifu ya kristaline yera, hafi yo kudashonga mumazi, gushonga byoroshye muri chloroform, gushonga cyane muri methanol na Ethanol, byoroshye kuri pyrolyze, aho gushonga ni 40 ℃～ 42 ℃. Molekile yayo ni diastereomer irimo santere enye za chiral, ku burebure bwa 529nm, igisubizo cyacyo cya Ethanol gifite rotation optique.
Uburyo bwibikorwa
Orlistat ni ndende ikora kandi ikomeye cyane ya gastrointestinal lipase inhibitor, idakora imisemburo ibiri yavuzwe haruguru ikora isano ya covalent hamwe na serine ikora ya lipase munda no munda mato. Imisemburo idakora ntishobora kugabanya ibinure mu biryo mo aside irike yubusa hamwe na glycerol ya Chemicalbook ishobora kwinjizwa numubiri, bityo kugabanya ibinure no kugabanya ibiro. Byongeye kandi, ubushakashatsi bumwe bwerekanye ko orlistat ibuza kwinjiza amara ya cholesterol mu kubuza niemann-gutora C1 isa na poroteyine 1 (niemann-pickC1-nka1, NPC1L1).
Ibyerekana
Iki gicuruzwa gifatanije nimirire yoroheje ya hypocaloric cyerekanwe kuvura igihe kirekire kubantu bafite umubyibuho ukabije kandi bafite ibiro byinshi, harimo nabafite ingaruka ziterwa no kubyibuha. Iki gicuruzwa gifite uburemere bwigihe kirekire (kugabanya ibiro, kubungabunga ibiro no kwirinda kugaruka). Gufata orlistat birashobora kugabanya ingaruka ziterwa numubyibuho ukabije hamwe nizindi ndwara ziterwa numubyibuho ukabije, harimo hypercholesterolemia, diyabete yo mu bwoko bwa 2, kwihanganira glucose, hyperinsulinemia, hypertension, hamwe no kugabanya ibinure byamavuta.
Imikoranire y'ubuvuzi
Irashobora kugabanya kwinjiza vitamine A, D na E. Irashobora kongerwaho nibicuruzwa icyarimwe. Niba urimo gufata imyiteguro irimo vitamine A, D na E (nka vitamine zimwe na zimwe), ugomba gufata iki gicuruzwa nyuma yamasaha 2 ufashe iki gicuruzwa cyangwa mugihe cyo kuryama. Abantu barwaye diyabete yo mu bwoko bwa 2 barashobora gukenera kugabanya urugero rwa hypoglycemic yo mu kanwa (urugero, sulfonylureas). Gufatanya na cyclosporine birashobora gutuma igabanuka rya plasma yibyanyuma. Gukoresha neza amiodarone birashobora gutuma igabanuka ryanyuma hanyuma bikagabanuka.
