Ibikoresho bya Farma
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Fmoc-Lys (Pal-Glu-OtBu) -OH
Fmoc-Lys (Pal-Glu-OtBu) -OH numuyoboro wihariye wa lipide ya amino acide yagenewe peptide - lipid conjugation. Iranga lysine irinzwe na Fmoc hamwe na palmitoyl-glutamate kumurongo wuruhande, byongera membrane isano hamwe na bioavailability.
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Fmoc-We-Aib-OH
Fmoc-His-Aib-OH ni inyubako ya dipeptide ikoreshwa muri synthesis ya peptide, ihuza histidine irinzwe na Fmoc na Aib (acide α-aminoisobutyric). Aib itangiza gukomera, bigatuma igira agaciro mugushushanya peptide ihamye kandi ihamye.
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Boc-We (Trt) -Aib-Glu (OtBu) -Gly-OH
Boc-His (Trt) -Aib-Glu (OtBu) -Gly-OH ni agace ka tetrapeptide karinzwe gakoreshwa muri synthesis ya peptide no guteza imbere ibiyobyabwenge. Irimo amatsinda yimikorere ikingiwe muburyo bwo guhuza intambwe hamwe nibiranga Aib (α-aminoisobutyric aside) kugirango yongere imbaraga za helix hamwe no gukomera.
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU ni molekile ya sintetike ya lipide ihuza molekile yagenewe gutanga ibiyobyabwenge hamwe na antibody - ibiyobyabwenge (ADCs). Irimo stearoyl (Ste) hydrophobic umurizo, gl-glutamyl igamije motif, icyogajuru cya AEEA kugirango gihindurwe, hamwe nitsinda rya OSu (NHS ester) kugirango rihuze neza.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH ni inyubako ikingira inyubako ya tripeptide ikingira igizwe na α-methylated leucine, ikoreshwa cyane mugushushanya imiti ya peptide kugirango iteze imbere metabolike no guhitamo reseptor.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) ni intungamubiri ya zwitterionic ikoreshwa cyane mubushakashatsi bwa poroteyine ya membrane na biologiya yubatswe, cyane cyane muri NMR spectroscopy na kristu.
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Donidalorsen
Donidalorsen API ni antisense oligonucleotide (ASO) iri gukorwaho iperereza kugirango ivure umurage wa angioedema (HAE) hamwe nindwara ziterwa na inflammatory. Yizwe murwego rwa RNA igamije kuvura, igamije kugabanya imvugo yaplasma prekallikrein(KLKB1 mRNA). Abashakashatsi bifashisha Donidalorsen kugira ngo basuzume uburyo bwo gucecekesha gene, imiti iterwa na farumasi, no kugenzura igihe kirekire kurwanya indwara ya bradykinin.
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Fitusiran
Fitusiran API ni sintetike ntoya yivanga RNA (siRNA) yakozweho iperereza cyane cyane mubijyanye na hemofilia n'indwara ya coagulation. Ireba iantithrombine (AT cyangwa SERPINC1)gene mu mwijima kugirango igabanye umusaruro wa antithrombine. Abashakashatsi bifashisha Fitusiran kugira ngo basuzume uburyo RNA yivanga (RNAi), gucecekesha gene yihariye y’umwijima, hamwe n’ingamba zo kuvura udushya zo kongera guhuza imitsi mu barwayi ba hémofilia A na B, hamwe na inhibitor.
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Givosiran
Givosiran API ni sintetike ntoya yivanga RNA (siRNA) yize kugirango ivure poropiya ikaze ya hepatike (AHP). Irasa cyane cyane iALAS1gene (aminolevulinic acide synthase 1), igira uruhare munzira ya heme biosynthesis. Abashakashatsi bifashisha Givosiran kugira ngo bakore iperereza ku buvuzi bwa RNA (RNAi) bushingiye ku buvuzi, gucecekesha gene igamije umwijima, no guhindura inzira za metabolike zigira uruhare muri porphiriya n'indwara zishingiye ku ngirabuzima fatizo.
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Plozasiran
Plozasiran API ni sintetike ntoya yivanga RNA (siRNA) yatejwe imbere yo kuvura hypertriglyceridemia hamwe nindwara zifata umutima nimiyoboro hamwe na metabolike. Ireba iAPOC3gene, igizwe na apolipoprotein C-III, igenga urufunguzo rwa metabolism ya triglyceride. Mu bushakashatsi, Plozasiran akoreshwa mu kwiga ingamba zo kugabanya lipide zishingiye kuri RNAi, gucecekesha gene, no kuvura igihe kirekire ku bihe nka syndrome de famille chylomicronemia (FCS) hamwe na dyslipidemiya ivanze.
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Zilebesiran
Zilebesiran API ni iperereza rito ryivanga RNA (siRNA) ryakozwe kugirango rivure hypertension. Ireba iAGTgene, igizwe na angiotensinogen-igice cyingenzi cya sisitemu ya renin-angiotensin-aldosterone (RAAS). Mu bushakashatsi, Zilebesiran akoreshwa mu kwiga uburyo bwo gucecekesha gene mu gihe cyo kurwanya umuvuduko w’amaraso igihe kirekire, tekinoroji yo gutanga RNAi, n’uruhare runini rw’inzira ya RAAS mu ndwara zifata umutima ndetse n’impyiko.
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Caspofungin yo kwandura Antifungal
Izina: Caspofungin
Numero ya CAS: 162808-62-0
Inzira ya molekulari: C52H88N10O15
Uburemere bwa molekuline: 1093.31
EINECS Numero: 1806241-263-5
Ingingo yo guteka: 1408.1 ± 65.0 ° C (Biteganijwe)
Ubucucike: 1.36 ± 0.1 g / cm3 (Biteganijwe)
Coefficient ya acide: (pKa) 9.86 ± 0.26 (Biteganijwe)