Caspofungin yo kwandura Antifungal
Ibisobanuro birambuye
| Izina | Caspofungin |
| Numero ya CAS | 162808-62-0 |
| Inzira ya molekulari | C52H88N10O15 |
| Uburemere bwa molekile | 1093.31 |
| Umubare wa EINECS | 1806241-263-5 |
| Ingingo yo guteka | 1408.1 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.36 ± 0.1 g / cm3 (Biteganijwe) |
| Coefficient ya acide | (pKa) 9.86 ± 0.26 (Biteganijwe) |
Synonyme
CS-1171; Caspofungine; CASPOFUNGIN; CASPORFUNGIN; PneuMocandinB0,1 - [(4R, 5S) -5 - [(2-aMinoethyl) aMino] -N2- L-ornithine] -5 - ((3R) -3-hydroxy-L-ornithine] -;
Ibikoresho bya Shimi
Caspofungin niyo echinocandine yambere yemerewe kuvura indwara zanduza.Muri vitro no muri vivo ubushakashatsi bwemeje ko caspofungin ifite ibikorwa byiza bya antibacterial kurwanya virusi zikomeye-Candida na Aspergillus.Caspofungin irashobora gusenya urukuta rw'akagari mu guhagarika synthesis ya 1,3-β-glucan.Mubuvuzi, caspofungin igira ingaruka nziza mukuvura candidiasis zitandukanye na aspergillose.
Ingaruka
(1)Nyuma yubuyobozi bwimitsi, ibiyobyabwenge bya plasma bigabanuka vuba kubera gukwirakwiza ingirangingo, bigakurikirwa no gusohora buhoro buhoro ibiyobyabwenge biva mubice.Metabolism ya caspofungin yiyongereye hamwe no kwiyongera kwinshi kandi byari bifitanye isano nigihe cyo guhagarara neza hamwe na dosiye nyinshi.Kubwibyo, kugirango tugere ku ntera nziza yo kuvura no kwirinda kwirundanyiriza ibiyobyabwenge, hagomba gutangwa ikinini cya mbere cyo gupakira hanyuma kigakurikiranwa.Iyo ukoresheje cytochrome p4503A4 inducers icyarimwe, nka rifampicin, karbamazepine, dexamethasone, phenytoin, nibindi, birasabwa kongera urugero rwo gufata neza caspofungin.
Ibyerekana
Ibimenyetso byemewe na FDA kuri caspofungin birimo: 1. Umuriro ufite neutropenia: usobanurwa ngo: umuriro> 38 ° C hamwe na neutrophil yuzuye (ANC) ≤500 / ml, cyangwa hamwe na ANC ≤1000 / ml kandi biteganijwe ko ishobora kugabanuka. kugeza munsi ya 500 / ml.Dukurikije ibyifuzo by’umuryango w’indwara zandura muri Amerika (IDSA), nubwo abarwayi bafite umuriro udahoraho na neutropenia bavuwe na antibiyotike yagutse, abarwayi bafite ibyago byinshi baracyasabwa gukoresha imiti igabanya ubukana bwa virusi, harimo caspofungine n’ibiyobyabwenge bya antifungali. ..2. Indwara ya kandidatire itera: IDSA irasaba echinocandine (nka caspofungin) nk'umuti wo guhitamo kandida.Irashobora kandi gukoreshwa mu kuvura ibisebe byo munda, peritonite n'indwara zo mu gatuza ziterwa na Candida.3. Esiphageal candidiasis: Caspofungin irashobora gukoreshwa mukuvura kandidiasis esophageal kubarwayi bafite kwanga cyangwa kutihanganira ubundi buvuzi.Ubushakashatsi bwinshi bwerekanye ko ingaruka zo kuvura caspofungin zigereranywa na fluconazole.4. Invasive aspergillose: Caspofungin yemerewe kuvura aspergillose itera abarwayi bafite kutihanganirana, kutarwanya, no kudakora neza kumiti nyamukuru ya antifungal, voriconazole.Ariko, echinocandin ntabwo isabwa nkumurongo wambere wo kuvura.
