Rapamycin ni ibiyobyabwenge bya Immunuppressive, Kurwanya kanseri no kurwanya anti-ap
Ibisobanuro birambuye
| Izina | Rapamycin |
| Umubare wa Cas | 53123-88-9 |
| Formulala | C51H79NO13 |
| Uburemere bwa molekile | 914.19 |
| Umubare wa EINECS | 610-965-5 |
| Ingingo itetse | 799.83 ° C (Byahanuwe) |
| Ubucucike | 1.0352 |
| Imiterere | Yashyizweho ikimenyetso cyumye, ububiko muri firigo, munsi ya -20 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Gupakira | Pe Umufuka + Umufuka wa Aluminium |
Synonyme
Ay 22989; 23,27-epoxy-3h-pyrido (2,1-cy) (1,4); rapamycine; rapamycin, speamycin, stromycice hygroscopicus; rpm
Ingaruka ya farumasi
Ibisobanuro
Rapamycin ni antibiyotike ya macrolide isa na procofol (fk506), ariko ifite uburyo butandukanye cyane myinsuppression. FK506 ibuza itandukaniro rya T lymphocytes yo muri G0 icyiciro cya G0 kugeza G1, mu gihe Rapa irashobora guhagarika inzira ya Cytokine, ugereranije na FKSON6, Rapa irashobora guhagarika inzira ya Cytokine hamwe na FIPAPH-POLChocytes ya T na Blmphocytes. Kaminuza ishinzwe ubuvuzi bwa Chicago bakoresha ubucuruzi bwimikorere ya rapamycine wongeyeho umutobe w'inzabibu wo gufata melanoma, indwara zisanzwe zo mu Burayi zifata nk'ingaruka zidasanzwe z'ibindi biyobyabwenge, bityo bikaba biranga igihe cyo kubaho. Ubushakashatsi bwerekanye ko Rapamycin yangirika byoroshye na enzymes nyuma yo kwinjira mu nzira y'amazi, kandi umutobe w'inzabibu urimo ingano ya Furanocoumarins, ishobora kubuza ingaruka zangiza imiyoboro y'igifuniko kuri Rapamycin. Irashobora kunoza ibinyabuzima bya Rapamycin. Bavuga ko abaganga ba mbere bo mu Buholandi bavumbuye ko umutobe w'inzabibu ufite ingaruka zo kunoza umunwa, none abaganga bo mu bihugu by'Uburayi n'Abanyamerika babishyize mu bikorwa bya Rapamycin.
Mu myaka yashize, ubushakashatsi bwabonye ko intego ya Rapamycin (Mtor) ari kinase yinzira, kandi inzira idasanzwe yo gukora irashobora gutera indwara zitandukanye. Nk'abakinnyi bagenewe Mtor, Rapamycin arashobora kuvura ibibyimba bijyanye n'iyi nzira, harimo na kanseri y'ingoma, kanseri y'ibihaha, kanseri y'umwijima, kanseri y'ibere. Cyane cyane mu kuvura indwara ebyiri zidasanzwe, Lam (lymphangioMomatototosos) na TSC (sclerose ya Tuberous), ingaruka ziragaragara kandi, litiro na tsc na tsc zirashobora gufatwa nkindwara zo kwigitarungano kurwego runaka.
Ingaruka
Rapamycin (RAPA) ifite ingaruka nkizo kuri FK506. Mu bigeragezo byinshi by'amavuriro, ingaruka zayo zabonetse ko zishingiye kandi zishingiye kandi zihinduka, na RAPA ku birori byo kuvura ntibyabonetse kugira ngo hatabonetse neppetoxie. Ingaruka nyamukuru kandi kuruhande zirimo: kubabara umutwe, isesemi, kuzunguruka, amazuru, no kubabara hamwe. Laboratory abnormalities include: thrombocytopenia, leukopenia, low hemoglobin, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, elevated liver enzymes (SGOT, SGPT), elevated lactate dehydrogenase, hypokalemia, Hypomagnesemia, etc. Eyelid edema Yaherutse kuvugwa hamwe nubuyobozi bwa Rapa, nimpamvu yinzego zo hasi ya plasma ya plasma yatekerejweho kwibeshya kuva impyiko zaciwe na rapa-ishingiye kumutima wa Imyumbati. Kimwe n'abandi bay'umummununpressions, Rapa ifite amahirwe yo kwandura, hamwe no kongera umusonga byumwihariko, ariko ibintu byabaye byo kwandura amahirwe bitari bitandukanye cyane na CSA.
