Sildenafil Citrate ivura imikorere mibi ya Erectile 171599-83-0
Ibicuruzwa birambuye
| Izina | Sildenafil Citrate |
| Numero ya CAS | 171599-83-0 |
| Inzira ya molekulari | C28H38N6O11S |
| Uburemere bwa molekile | 666.70 |
| Umubare wa EINECS | 200-659-6 |
| Merk | 14.8489 |
| Ubucucike | 1.445g / cm3 |
| Imiterere y'ububiko | 2-8 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Amazi meza | DMSO:> 20mg / mL |
Synonyme
Viagra, citrate ya Sildenafil; 1 - [[3- (4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo 5- [2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo 1 - [[3- (6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo SildenafilCitrate (100mg); Sildenafilcitrate,> = 99%; Sildenafilcitrate, Abanyamwuga; 5- [2-Ethoxy-5 - [(4
Ingaruka ya Farumasi
Igikorwa cya farumasi
Citrate ya Sildenafil ni intiti ya 5-fosifisiyose itoranya itera imbaraga za nitric oxyde iterwa na nitric oxyde, cyclic guanosine monophosphate-medrated pulmonary vasodilation ikabuza gusenyuka kwa monosifike ya sikeli. Usibye kwaguka mu buryo butaziguye imiyoboro y'amaraso y'ibihaha, irashobora kandi gukumira cyangwa guhindura imiyoboro y'amaraso.
Ibyiza byubuvuzi nibisabwa
Citrate ya Sildenafil, izina ry'ubucuruzi Viagre, bakunze kwita Viagra, ni cyclic guanosine monophosphate (cGMP) -ibikoresho byihariye bya fosifisiyose yo mu bwoko bwa 5 (PDE5) inhibitor ishobora kuzamura ubwubatsi nyuma yubuyobozi bwo mu kanwa. Sildenafil citrate irashobora kongera ingaruka za okiside ya nitric (OYA) muguhagarika ubwoko bwa 5 bwa fosifisiyose ibora cyclic guanosine monophosphate (cGMP) muri corpus cavernosum. Ongera urwego rwa cGMP muri corpus cavernosum, humura imitsi yoroshye muri corpus cavernosum, wongere amaraso, wongere igihe cyo gutera imboro kandi wongere gukomera. Kubarwayi badafite imbaraga bafite imikorere mibi. Abakuze bafata mg 50 mu kanwa buri gihe, kugeza inshuro 1 kumunsi, bakayikoresha nkuko bikenewe mbere yisaha 1 mbere yimibonano mpuzabitsina. Umubare ntarengwa ni 0.1g buri gihe.
Mu bushakashatsi bwa vivo
Mu mbwa zatewe aneste, citrate ya Sildenafil yongerera imbaraga igitsina gore munsi yimyanya myibarukiro yo gupima umuvuduko ukabije. Sildenafil citrate yahinduye ku buryo bugaragara imyuka ya karbamoylcholine yatewe no kwidagadura kandi ikabuza gukora superoxide mu mitsi ya cavernosal yinkwavu za hypercholesterolemic. Imbeba za Sprague-Dawley, Sildenafil itezimbere imikorere yumugabo muburyo buterwa nigihe, hamwe no gukira kwinshi kugaragara kumunsi wa 28 kumupanga wa mg / kg 20 kumunsi. Imbeba za Sprague-Dawley, ubuyobozi bwa Sildenafil bwatumye imitsi ya kolagen igabanuka neza no kubungabunga CD31 na eNOS. Imbeba za Sprague-Dawley, Sildenafil yagabanije cyane indangagaciro ya apoptotique kandi yongera fosifora ya akt na eNOS ugereranije nitsinda rishinzwe kugenzura.
