Sildenafil Umunyamerika avura imikorere mibi 171599-83-0
Ibisobanuro birambuye
| Izina | Sildenafil citrate |
| Umubare wa Cas | 171599-83-0 |
| Formulala | C28H38N6o11s |
| Uburemere bwa molekile | 666.70 |
| Umubare wa EINECS | 200-659-6 |
| Merck | 14.8489 |
| Ubucucike | 1.445G / CM3 |
| Imiterere | 2-8 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Amazi | Dmso:> 20mg / ml |
Synonyme
Viagra, Sildenafil citrate; 1. 5- (2 1. Sildenafilcilcitrate (100mg); SilsenafilCiter,> = 99%; silsenafilcterate, ubigize umwuga; 5- (1
Ingaruka ya farumasi
Ibikorwa bya farumasi
Sildenafil Citrate ni uhitamo 5-Fopsopholsterase infashanyigisho iterwa na nitric monohoshaste, ihanaguwe na cyclic igifuniko cya monophine cya monopline mu kubuza gusenyuka kwa Cycrophosmosine Monophos. Usibye kwaguka mu buryo butaziguye imiyoboro y'amaraso ya lubmoni, irashobora kandi gukumira cyangwa guhindura imiyoboro y'amaraso.
Imiti ivura hamwe na porogaramu
Sildenafil Citrate, Izina ryubucuruzi Viagre, usanzwe uzwi nka viagra, ni guanosine monophoshate (cgmp)-pde5) ibikoresho bishobora guhungabanya enhibite ishobora kongeramo ubuyobozi bwakanwa. Sildenafil citrate irashobora kongera ingaruka za Nitric oxyde (oya) mu kubuza ubwoko bwa fosiposito 5 bubora koclic guanosine monophosphate monophosphate (cgmp) muri corpus cavernosum. Ongera urwego rwa CGMP muri Corpus Cavernosum, humura imitsi yoroshye muri corpus cavernosum, ongeraho amaraso, ujye umwanya wamaraso, wongere umwanya wo kwerekana imboro kandi wongere ushikamye. Kubarwayi badafite amavuta bafite imbaraga zidahwitse. Abantu bakuru bafata mg 50 buri gihe, kugeza kumwanya 1 kumunsi, kandi bagakoresha nkuko bikenewe hakenewe amasaha 1 mbere yimibonano mpuzabitsina. Umubare ntarengwa ni 0.1G buri gihe.
Mu bushakashatsi bwa Vivo
Mu mbwa ya anesthetise, Sildenafil ifite citrate yoroshye imikorere yimikorere yimikorere ya pelvic yangiza imitsi yo gupima igitutu cya interineti. Sildenafil citrate yasubiwemo ku buryo bugaragara ku buruhukiro bwa carbamoycholine kandi bugaburira iperereza rya Superoxide mu turere twa cavernoside mu tuvukwa hypercholesterole. Muri Sprague-Dawley Imbeba, Sildenafil itezimbere imikorere yubuzima mugihe giterwa nigihe-gitunzwe, hamwe no gukira kwambere bibaye kumunsi wa 28 kuri 20 MG / kg kumunsi. Muri Sprague-DAWLEY, Ubuyobozi bwa Sildenafil bwatumye rubanda rworoshye rwo kubungabunga no kubungabunga CD31 na Enos. Muri Sprague-DAWLEY, SIFENAFIl yagabanije cyane indangagaciro zidasanzwe kandi yongeraho fososhorylation ya Akt na Enos ugereranije n'itsinda rishinzwe kugenzura.
