Tadalafil 171596-29-5 Guvura Dysile Disikizi Yakoze Mubigabo

Tadalafil (Tadalafil, Tadalafil) afite formulaire ya C22H19993O4 nuburemere bwa molekile bwa 389.4. Byakoreshejwe cyane mugufata nabi abagabo ba data kuva mu 2003, hamwe nizina ryubucuruzi cialis (cialis). Muri Kamena 2009, FDA yemeje Tadalafil muri Amerika kugira ngo bavure abarwayi bafite hymerial hypertension (pah) munsi yizina ryubucuruzi adcirca. Tadalafil yatangijwe mu 2003 nk'ibiyobyabwenge byo kuvura ED. Bitangira gukurikizwa iminota 30 nyuma yubuyobozi, ariko ingaruka nziza ni 2h nyuma yo gutangira ibikorwa, kandi ingaruka zishobora kumara 36h, kandi ingaruka zayo ntizigira ingaruka kubiryo. Igipimo cya Tadalafil ni 10 cyangwa 20 mg, igitekerezo cya mbere ni mg 10, kandi igipimo gihindurwa ukurikije igisubizo cyumurwayi nibitekerezo bibi. Ubushakashatsi bwambere bwerekanye ko nyuma yubuyobozi bwo mu kanwa bwa MG 10 cyangwa 20 ya Tadalafil ibyumweru 12, umubare mwiza ni 67% na 81%. Ubushakashatsi bwinshi bwerekanye ko Tadalafil afite imikorere myiza mu kuvura ibya ED.

Imikorere idahwitse: Tadalafil ni uburyo bwo guhitamo fosphorsterase 5 (pde5) nka Silsenafil, ariko imiterere yacyo iratandukanye niyanyuma, kandi imiterere ya nyuma ntabwo ibangamira kwinjiza. Mubikorwa byangiza imibonano mpuzabitsina, synthaside ya nitric (Nos) mumitsi yingabo hamwe na vantalzile ya feriteleyes cataline ya nitric oxide ya nitric oxte l-Arginine. Nta gukora ishitsi cyclase, bihindura guanasine Triphosphate muri cyclic Guanosine monoplic kions, bitera kugabanuka kwa Corciplasphate, bitera kwibanda kuri crotesine ya Corciphosphate Ubwoko bwa fosiphomsterase 5 (pde5) bitesha agaciro cgmp mubicuruzwa bidakora, bigatuma imboro muburyo budakomeye. Tadalafil ibuza gutesha agaciro PDE5, biganisha ku kwegeranya CGMP, biruhura imitsi yoroshye ya corpus cavernosum, biganisha ku kwiyongera kw'impanuka. Kubera ko ari abaterankunga badafite abaterankunga, bahujwe no gukoresha Tadalafil bazakongera cyane urwego rwa CGMP kandi baganisha ku myanda ikomeye. Kubwibyo, gukoresha hamwe byombi byandujwe mubikorwa byubuvuzi.

Tadalafil akora mu kubuza pdes. GMP irateshwa agaciro, ihuriweho cyane no gukoresha nitrate zishobora gutera igitonyanga gikabije mumitutu rwamaraso no kongera ibyago byunana. CY3PA4 inducers will reduce the bioavailability of tadanafil, and the combination with rifampicin, cimetidine, erythromycin, clarithromycin, itracon, ketocon, and HVI protease inhibitors may increase the The blood concentration of the drug should be adjusted. Kugeza ubu, nta makuru avuga ko ibipimo bya farumasikotike by'ibi bicuruzwa bigira ingaruka ku mirire n'inzoga.