Tadalafil 171596-29-5 kuvura Imikorere mibi ya Erectile kubagabo

Tadalafil (Tadalafil, Tadalafil) ifite formulaire ya C22H19N3O4 hamwe nuburemere bwa molekile ifite 389.4. Yakoreshejwe cyane mukuvura imikorere mibi yumugabo kuva 2003, hamwe nizina ryubucuruzi Cialis (Cialis). Muri Kamena 2009, FDA yemeje tadalafil muri Amerika kuvura abarwayi bafite hypertension yimpyiko (PAH) ku izina ry’ubucuruzi Adcirca. Tadalafil yatangijwe mu 2003 nk'umuti wo kuvura ED. Itangira gukurikizwa nyuma yiminota 30 nyuma yubuyobozi, ariko ingaruka nziza ni 2h nyuma yigikorwa gitangiye, kandi ingaruka zirashobora kumara 36h, kandi ingaruka zayo ntiziterwa nibiryo. Igipimo cya tadalafil ni mg 10 cyangwa 20 mg, icyifuzo cya mbere gisabwa ni mg 10, kandi ikinini gihindurwa ukurikije igisubizo cy’umurwayi ndetse n’ingaruka mbi. Ubushakashatsi bwabanjirije isoko bwerekanye ko nyuma yubuyobozi bwo mu kanwa bwa mg 10 cyangwa 20 za tadalafil mu byumweru 12, ibiciro byiza ni 67% na 81%. Ubushakashatsi bwinshi bwerekanye ko tadalafil ifite imikorere myiza mukuvura ED.

Imikorere mibi ya Erectile: Tadalafil ni fosifisiyose yatoranijwe yo mu bwoko bwa 5 (PDE5) nka sildenafil, ariko imiterere yayo itandukanye niyanyuma, kandi indyo yuzuye amavuta ntabwo ibangamira iyinjira ryayo. Mubikorwa byo gukangura imibonano mpuzabitsina, synthase ya nitric oxyde (NOS) mumyanya ndangagitsina ya penile na selile endothelia selile itera synthesis ya nitric oxyde (OYA) iva muri substrate L-arginine. OYA ikora guanylate cyclase, ihindura guanosine triphosphate na cyclic guanosine monophosphate (cGMP), bityo igakora cyclic guanosine monophosphate iterwa na protein kinase, bigatuma igabanuka ryikwirakwizwa rya ion ion ya calcium mungirangingo yimitsi yoroshye, bigatuma imitsi ya corpus cavernosum ibaho. Ubwoko bwa Phosphodiesterase ubwoko bwa 5 (PDE5) butesha agaciro cGMP mubicuruzwa bidakora, bigatuma imboro ihinduka intege nke. Tadalafil ibuza kwangirika kwa PDE5, biganisha ku kwegeranya kwa cGMP, koroshya imitsi yoroshye ya corpus cavernosum, biganisha ku gutera imboro. Kubera ko nitrate NTA baterankunga, gukoresha hamwe na tadalafil bizamura cyane urwego rwa cGMP kandi biganisha kuri hypotension ikabije. Kubwibyo, gukoresha hamwe byombi birabujijwe mubikorwa byubuvuzi.

Tadalafil ikora mukubuza PDES. GMP yangiritse, bityo gukoresha hamwe na nitrate bishobora gutera umuvuduko ukabije wumuvuduko wamaraso kandi byongera ibyago bya syncope. Indwara ya CY3PA4 izagabanya bioavailable ya tadanafil, kandi hamwe na rifampicin, cimetidine, erythromycine, clarithromycin, itracon, ketocon, na protease HVI bishobora kongera amaraso yibiyobyabwenge bigomba guhinduka. Kugeza ubu, nta makuru avuga ko ibipimo bya farumasi bikoreshwa muri ibyo bicuruzwa bigira ingaruka ku mirire n'inzoga.