Tirzepatide
Tirzepatide API
Tirzepatide ni peptide yubukorikori ikora nka peptide ikora nka agonisti ya glucose iterwa na insulineotropique polypeptide (GIP) hamwe na glucagon imeze nka peptide-1 (GLP-1). Irerekana icyiciro gishya cyubuvuzi bushingiye kuri incretin buzwi ku izina rya “twincretine”, butanga uburyo bunoze bwo kugenzura metabolike ku barwayi bafite diyabete yo mu bwoko bwa 2 n'umubyibuho ukabije.
Tirzepatide API yacu ikorwa hifashishijwe tekinoroji ya chimique yateye imbere, ikemeza ko isuku ihanitse, urwego ruke rw’umwanda, hamwe nicyiciro cyiza cyane. Bitandukanye na peptide ikomoka kuri rDNA, API yacu yubukorikori idafite poroteyine zakira na ADN, byongera cyane ibinyabuzima no kubahiriza amategeko. Ibikorwa byo gukora byatejwe imbere kugirango habeho gukenera isi yose.
Uburyo bwibikorwa
Tirzepatide ikora icyarimwe itera icyarimwe GIP na GLP-1, itanga ingaruka zuzuzanya no guhuza:
Gukora GIP yakira: byongera insuline kandi birashobora kunoza insuline.
GLP-1 yakira reseptor: ihagarika glucagon irekura, itinda gusiba gastric, kandi igabanya ubushake bwo kurya.
Ibikorwa bihuriweho biganisha kuri:
Kunoza igenzura rya glycemic
Kugabanuka k'uburemere bw'umubiri
Kongera guhaga no kugabanya ibiryo
Ubushakashatsi bwa Clinical & Ibisubizo
Tirzepatide yerekanye imbaraga zitigeze zibaho mu bigeragezo byinshi binini by’amavuriro (SURPASS & SURMOUNT):
Kugabanuka gusumba HbA1c ugereranije na GLP-1 RAs (urugero, Semaglutide)
Kugabanuka ibiro bigera kuri 22.5% kubarwayi bafite umubyibuho ukabije - ugereranije no kubaga ibibari rimwe na rimwe
Gutangira vuba kwingaruka no kuramba glycemic kugenzura kumara igihe kirekire
Kumenyekanisha ibimenyetso byumutima: harimo umuvuduko wamaraso, lipide, hamwe no gutwika
Tirzepatide ntabwo ivugurura gusa uburyo bwo kuvura diyabete yo mu bwoko bwa 2 ahubwo igaragara nkuburyo bukomeye bwo kuvura kugabanya ibiro byubuvuzi hamwe na syndrome de metabolike.
Ubwiza & Kubahiriza
API yacu ya Tirzepatide:
Yujuje ubuziranenge bwisi yose (FDA, ICH, EU)
Yageragejwe binyuze muri HPLC kurwego rwo hasi rwumwanda uzwi kandi utazwi
Yakozwe mubihe bya GMP hamwe nibikorwa byuzuye
Shigikira umusaruro munini R&D
