Vardenafil Diorddrochloride ivura Dysile Diekeli 224785-91-5
Ibisobanuro birambuye
| Izina | Vardenafil Diorddrochloride |
| Umubare wa Cas | 224785-90-4-90-4-9-4-90-4-90-4 |
| Formulala | C23h32N6o4s |
| Uburemere bwa molekile | 488.6 |
| Umubare wa EINECS | 607-088-5 |
| Gushonga | 230-235 ° C. |
| Ubucucike | 1.37 |
| Imiterere | Yashyizweho ikimenyetso cyumye, ububiko muri firigo, munsi ya -20 ° C. |
| Ifishi | Ifu |
| Ibara | Cyera |
| Coeffity | (PKA) 9.86 ± 0.20 (byahanuwe) |
Synonyme
VardenaFil (uvugwa mu ngingo 5-. VarseNenafilhydrochloridentridrings99%; VardenafilhydrochlorsetrihydrihydAtes CAS # 224785-90-4-9-9-9-9-90-4-90-4-90-4-90-4-90-4-90-4-90-4-90-4-90-4-90-4-90-4-90-4-9 AbakorarsrssuplbestvalityGalityGalityGalityGalityGalityGarilhyhyhyhyhyhyhloridentridyetrihydrihydrihydrihythhyDarate224785-90-4CASNO.22785-90-4; [3,4-diydro-5- methyl-4-ox
Ingaruka ya farumasi
Ibikorwa bya farumasi
Iyi miti ni phophoersterase ubwoko bwa 5 (pde5) inhibitor. Ubuyobozi bwo mu kanwa burashobora kunoza ubuziranenge nigihe cyo kwiyongera, no kunoza igipimo cyo gutsinda mubuzima bwimibonano mpuzabitsina mubarwayi b'igitsina gabo bafite ubushize. Gutangiza no gufata neza kwihitiramo impumuro ishingiye ku buruhukiro bwa cavernossal, kandi cymplic ya Guanasine Monophosphate (cgmp) ni umuhuza wo kuruhuka ingirabuzimafatizo za cavernosal. Iyi miti ibuza kwangirika kwa CGMP mu kubuza ubwoko bwa 5, bityo bigatera kwegeranya CGMP, kuruhuka imitsi yoroshye ya corpus cavernosum, no kugaburira imboro. Ugereranije na Fosiphomsserase Gusoftmes 1, 2, 3, 4, na 6, uyu muti ufite uburyo bworoshye bwa fosiposito 5. Amakuru amwe yerekana ko guhitamo no guhinduranya ingaruka kuri fosiphoersterase 5 iruta izindi myubateri za fosifori. Andika ubwoko bwa fosiphoerterase ababuza ni bake.
Imiti ivura hamwe na porogaramu
1. Iyo ikoreshwa hamwe na Cyp 3A4 (nka Ritonavir, Indinavir, ITHONOMOCANIL, Irashobora kubuza metabolism, nibindi byashize, kandi byongera ibintu byinshi mubuzima (nka Hypoteronsion, impinduka zigaragara, kubabara umutwe, isura yoroshye, priapism). Uyu muti ugomba kwirindwa hamwe na Ritonavir na Indinavir. Iyo bikoreshejwe hamwe na erythromycin, ketoCmonconazule, na Itrezozole, igipimo kinini cyiyi miti ntigikwiye kurenga MG 5, hamwe nigipimo cya KetoConconatozole na Itraccazole ntigomba kurenza Mg 200.
2. Abarwayi bafata nitrate cyangwa kwakira imiti ya Nitric OXCOR igomba kwirinda gukoresha ibiyobyabwenge. Uburyo bwacyo bwibikorwa nukukomeza kongeraKwibanda kuri CGMP, bikavamo ingaruka zongerewe imbaraga kandi ziyongereye kumutima. Iyo ikoreshwa hamwe na α-yakira abashyitsi, irashobora kuzamura ingaruka za antihyperte kandi iganisha kuri hypotension. Kubwibyo, gukoresha uyu muti birabujijwe kubakoresha α - Setstor Proctors. Indyo yo hagati (30% ya karori yabyibushye) nta ngaruka zikomeye kuri farumasikote ya metero imwe ya MG ya MG 20 yiyi miti no kugabanya amaraso yibanda kuri 18%.
Farumasikotics
Birahujwe byihuse nyuma yubuyobozi bwo mu kanwa, ibinyabuzima byuzuye bya tablet of Oral ni 15%, hamwe nigihe mpuzandengo cyo kwipinga 1h (0.5-2H). Igisubizo cya Oral 10mg cyangwa 20mg, impuzandengo ya peak ni 0.9h na 0.7h, impuzandengo ya plasma yibanze ni 9μg / l, kuri 21μ, Igipimo cyerekana iki kiyobyabwenge ni 95%. 1.5h nyuma yikigereranyo kimwe cya MG 20, ibiyobyabwenge mumasohoro ni 0.00018% yikinini. Ibiyobyabwenge biterwa ahanini mu mwijima muri cytochrome p450 (cyp) 3A4, n'amafaranga mato ni metabolied by cyp 3a5 na cyp 2C9 Isoenzymes. Metabolite nyamukuru ni M1 yashinzwe nimiterere yuburyo bwa piperazine yiyi miti. M1 ifite nanone ingaruka zo kubuza fosiphomsterase 5 (hafi 7% byimikorere yose), hamwe namaraso yayo ni 26% yo kwibanda kumaraso y'ababyeyi. , kandi irashobora gukomeza kuba metabolize. Igipimo cyo gusohoka cyibiyobyabwenge muburyo bwa metabolite mumyanda ninkari ni 91% kugeza 95% na 2% kugeza 6%. Igipimo rusange cyo gukuraho ni 56 l mu isaha, hamwe na kimwe cya kabiri cyubuzima bwababyeyi na M1 byombi bigera ku masaha 4 kugeza 5.
