Caspofungin yo kwandura Antifungal
Ibicuruzwa birambuye
| Izina | Caspofungin |
| Numero ya CAS | 162808-62-0 |
| Inzira ya molekulari | C52H88N10O15 |
| Uburemere bwa molekile | 1093.31 |
| Umubare wa EINECS | 1806241-263-5 |
| Ingingo yo guteka | 1408.1 ± 65.0 ° C (Biteganijwe) |
| Ubucucike | 1.36 ± 0.1 g / cm3 (Biteganijwe) |
| Coefficient ya acide | (pKa) 9.86 ± 0.26 (Byahanuwe) |
Synonyme
CS-1171; Caspofungine; CASPOFUNGIN; CASPORFUNGIN; PneuMocandinB0,1 - [(4R, 5S) -5 - [(2-aMinoethyl) aMino] -N2- (10,12-diMethyl -1-oxotetradecyl) -4-hydroxy-L-ornithine] -5 - [(3R) -3-hydroxy-L-ornithine] -;
Ibikoresho bya Shimi
Caspofungin niyo echinocandine yambere yemerewe kuvura indwara ziterwa na fungal. Muri vitro no muri vivo ubushakashatsi bwemeje ko caspofungin ifite ibikorwa byiza bya antibacterial kurwanya virusi zikomeye-Candida na Aspergillus. Caspofungin irashobora gusenya urukuta rw'akagari mu guhagarika synthesis ya 1,3-β-glucan. Mubuvuzi, caspofungin igira ingaruka nziza mukuvura kandidiasis zitandukanye na aspergillose.
Ingaruka
(1) Nyuma yubuyobozi bwimitsi, ibiyobyabwenge bya plasma bigabanuka vuba kubera gukwirakwiza ingirangingo, bikurikirwa no gusohora buhoro buhoro ibiyobyabwenge biva mubice. Metabolism ya caspofungin yiyongereye hamwe no kwiyongera kwinshi kandi byari bifitanye isano nigihe cyo guhagarara neza hamwe na dosiye nyinshi. Kubwibyo, kugirango tugere ku rwego rushimishije rwo kuvura no kwirinda kwirundanyiriza ibiyobyabwenge, hagomba gutangwa igipimo cya mbere cyo gupakira hanyuma hagakurikiraho imiti yo kubungabunga. Iyo ukoresheje cytochrome p4503A4 icyarimwe icyarimwe, nka rifampicin, karbamazepine, dexamethasone, phenytoin, nibindi, birasabwa kongera urugero rwo kubungabunga caspofungine.
Ibyerekana
Ibimenyetso byemewe na FDA kuri caspofungin birimo: 1. Umuriro ufite neutropenia: usobanurwa ngo: umuriro> 38 ° C hamwe na neutrophil yuzuye (ANC) ≤500 / ml, cyangwa hamwe na ANC ≤1000 / ml kandi biteganijwe ko ishobora kugabanuka munsi ya 500 / ml. Dukurikije icyifuzo cy’umuryango w’indwara zandura muri Amerika (IDSA), nubwo abarwayi bafite umuriro udahoraho na neutropenia bavuwe na antibiyotike yagutse, abarwayi bafite ibyago byinshi baracyasabwa gukoresha imiti igabanya ubukana bwa virusi, harimo caspofungine n’ibindi biyobyabwenge. . 2. Indwara ya candidiasis: IDSA irasaba echinocandine (nka caspofungin) nk'umuti wo guhitamo kandemiya. Irashobora kandi gukoreshwa mu kuvura ibisebe byo mu nda, peritonite n'indwara zo mu gatuza ziterwa na Candida. 3. Esiphageal candidiasis: Caspofungin irashobora gukoreshwa mukuvura kandidiasis esophageal abarwayi bafite ibibazo cyangwa kutihanganira ubundi buvuzi. Ubushakashatsi bwinshi bwerekanye ko ingaruka zo kuvura caspofungin zagereranywa na fluconazole. 4. Nyamara, echinocandin ntabwo isabwa nkumurongo wambere wo kuvura.
