Caspofungin kwandura antifungal
Ibisobanuro birambuye
| Izina | Caspofungin |
| Umubare wa Cas | 162808-62-0 |
| Formulala | C52H88n10O15 |
| Uburemere bwa molekile | 1093.31 |
| Umubare wa EINECS | 1806241-263-5 |
| Ingingo itetse | 1408.1 ± 65.0 ° C (Byahanuwe) |
| Ubucucike | 1.36 ± 0.1 g / cm3 (byahanuwe) |
| Coeffity | (PKA) 9.86 ± 0.26 (byahanuwe) |
Synonyme
CS-1171; Caspofungine; Caspofungin; Casporfungin; PnemocandinB0,1 - [(4r, 5s) -n2- (12,12-Dimethyl -1-Oxotetraecyl) -4-hydroxy-l-ornithine] -5 - [3R)-l-orpofunginmk-l-CaspoFine]
Imiti
Caspofungin yari Ecchinocandin yambere yemerewe kuvura indwara zigenda zitera. Muri Vitro no mu imyitozo ya Vivo yemeje ko Caspofungin afite ibikorwa byiza bya antibacteri kuri pathopens y'ingenzi - akandida na aspergillus. Caspofungin irashobora guturika urukuta rw'akagari abuza synthesis ya 1.3-β-glucan. Caspofungin, Caspofungin afite ingaruka nziza ku kuvura abadayisi zitandukanye na aspergillose.
Ingaruka
. Nyuma yubuyobozi bwimiterere, impeta yibiyobyabwenge ya Plasma yatonyanga vuba kubera gukwirakwiza tissue, hakurikiraho uburyo bwo gukemura buhoro buhoro ibiyobyabwenge bivuye muri tissue. Metabolism ya Caspofungin yiyongereye afite igipimo kandi yari igipimo-kijyanye nigihe cyo kuva muri dosiye nyinshi. Kubwibyo, kugirango tugere ku nzego nziza zo kuvura no kwirinda kwishyurwa ibiyobyabwenge, igipimo cya mbere cyo gupakira gikwiye gutangwa gikurikirwa nigipimo cyo kubungabunga. Iyo ukoresheje C4fchrome P4503A4 Inducers icyarimwe, nka RifaManshin, Carbanguru, Dexamethasone, Penyonthasone, Penyon, birasabwa kongera ibipimo byo kubungabunga Caspofungin.
Ibimenyetso
Amashusho yemewe ya FDA arimo: 1. Umuriro hamwe na Neutropenia: Byasobanuwe nka: Umuriro> 38 ° C hamwe na ANCT hamwe na NL kandi byahanuwe ko bishobora kugabanywa munsi ya 500 / ML. Nk'uko ibyifuzo byangiza indwara zanduza muri Amerika (Idsa), nubwo abarwayi bafite umuriro uhoraho na Neutropenia bamaze gukomera, harimo abarwayi bafite ibyago byinshi, harimo na caspofungine nibindi biyobyabwenge. . 2. Umukandida utera: Idsa irasaba Echinorins (nka Caspofungin) nkumuti wo guhitamo muri botidemia. Irashobora kandi gukoreshwa muguvura intra-indaya, peritonite nigituza nindwara yigituza giterwa na Candite yanduye. 3. Utabitire ya Esophage: Caspofungin arashobora gukoreshwa mugufata abadayisitiya ya Esophageal mu barwayi banze gutunganya cyangwa kutoroherana kubindi bikoresho. Ubushakashatsi bwinshi bwasanze ingaruka zo kuvura caspofungin ugereranije niya flushunazole. 4. Aspergilloses: Caspofungin yemerewe kuvura na aspergillose iteye ubwoba ku barwayi Ariko, Echinocandin ntabwo isabwa nkubuvuzi bwambere.
