Chondroitin Sulfate yo kuvura indwara z'umutima, arthritis no gukiza ibikomere bya corne
Ibisobanuro birambuye
| Izina | Chondroitin Sulfate |
| Umubare wa Cas | 9007-28-7 |
| Formulala | C13H21NO15S |
| Uburemere bwa molekile | 463.36854 |
| Umubare wa EINECS | 232-696-9 |
| Amazi | Gushonga mumazi |
| Ubuziranenge | 98% |
| Ububiko | Ububiko buri bushyuhe buri gihe |
| Ifishi | Ifu |
| Ibara | Cyera kuri off-cyera |
| Gupakira | Pe Umufuka + Umufuka wa Aluminium |
Synonyme
Poly-1 (2/3) -N-Acetyl-2-Amino-2-Deoxy-3-O-Beta-D-glucopyransyl-4- (6) sulfoorel-D-Galactose; Chondroitinpoly Sulfate; Chondroitin Slofates; Chondroiti Nsulfuricacid; Chondroitin aside sulfurike; Chosurid; CSO;
Ingaruka ya farumasi
Ibisobanuro
Chondroitinsulfate (CS) ni Mucopolsaccharide yakuweho kandi isukurwa ninyamaswa za Cartilage. Chondroitin Sulfate ifite imiterere itandukanye nka a, c, d, e, e na K. Chondroitin Sulfate, ifarasi, uruhu, Cornea, nazo zirimo. Ibikubiye muri Carkilage Amafi ari umukire cyane, nka 50% kugeza 60% mumagufwa ya shark, kandi bike cyane muri tissue.
Ku ndwara ya coroniclerotic, yongerewe lipids yamaraso na cholesterol, arteriosclerose, anginardia, ischemia, infate ya Myocardial, nibindi. Mu barwayi bafite indwara z'umutima.
Ibikorwa bya farumasi
Rapamycin (RAPA) ifite ingaruka nkizo kuri FK506. Mu bigeragezo byinshi by'amavuriro, ingaruka zayo zabonetse ko zishingiye kandi zishingiye kandi zihinduka, na RAPA ku birori byo kuvura ntibyabonetse kugira ngo hatabonetse neppetoxie. Ingaruka nyamukuru kandi kuruhande zirimo: kubabara umutwe, isesemi, kuzunguruka, amazuru, no kubabara hamwe. Laboratory abnormalities include: thrombocytopenia, leukopenia, low hemoglobin, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, elevated liver enzymes (SGOT, SGPT), elevated lactate dehydrogenase, hypokalemia, Hypomagnesemia, etc. Eyelid edema Yaherutse kuvugwa hamwe nubuyobozi bwa Rapa, nimpamvu yinzego zo hasi ya plasma ya plasma yatekerejweho kwibeshya kuva impyiko zaciwe na rapa-ishingiye kumutima wa Imyumbati. Kimwe n'abandi bay'umummununpressions, Rapa ifite amahirwe yo kwandura, hamwe no kongera umusonga byumwihariko, ariko ibintu byabaye byo kwandura amahirwe bitari bitandukanye cyane na CSA.
Ingaruka zabuxicologiya
Chondroitin Sulkate ibaho cyane cyane mumyanda ya Cartilage. Imyiteguro yiti cyane ikubiyemo isomers ebyiri za chondroitin sulfate a na chondroitin sulfate c, kandi ibikubiye muri Shondroitin sulfate yinyamaswa zamagare zitandukanye nimyaka itandukanye. Ingaruka za farumasi zikurikira: Shondroitin sulfate irashobora gukuraho lipids na lipoprotel mumaraso, irinde kandi ufate ibitero byamaraso, kandi byongera igipimo cya lipids na acide yibinure muri selile. Chondroitin Sulfate irashobora gukumira neza no kuvura indwara z'umutima. Ifite anti-athesclerose hamwe nicyapa cya anti-atherigenic ingaruka kuri Arteriosplerose yubushakashatsi; Yongera amashami ya coronary cyangwa ingwate ya Atherosclerose, kandi irashobora kwihutisha coronary arterise yubushakashatsi cyangwa embolism. Gukiza, kuvugurura no gusana ibyangombwa bya Myocardial cyangwa kwangirika. Irashobora kongera biosynthesis ya biosynthesi yintumwa ya selile riboncleic (MRNA) na acide deoxyribonucleic (ADN) kandi ifite ingaruka zo guteza imbere metabolism. Igikorwa gito gishinzwe anticoagulant. Chondroitin Sulfate ifite ingaruka zidasanzwe zidasanzwe, kandi buri 1 mg ya chondroitin sulfate a ihwanye nigikorwa kirwanya 0.45u ya heparin. Iki gikorwa kirwanya anticogulant ntabwo gishingiye kuri antitroromin III kugira uruhare rwayo, irashobora gukoresha ibikorwa birwanya irwanya fibrinogen. Chondroitin Sulfate nayo ifite anti-indumu, ibikomere byihuta gukiza no kurwanya ibibyimba.
